2. Autophagy Neuronal Signaling
  3. PINK1/Parkin Mitophagy Amyloid-β
  4. Y040-7904

Y040-7904 是一种潜在的线粒体自噬激动剂。Y040-7904 通过促进线粒体向自噬体的转运以及自噬体与自噬溶酶体的融合来增强线粒体自噬。Y040-7904 通过 SIRT1/FoxO3 通路诱导线粒体自噬。Y040-7904 上调 Parkin、PINK1 和 LC3II/I 的水平。Y040-7904 可减轻体外和体内阿尔茨海默病模型中的 Aβ 积累[1]。

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Y040-7904 Chemical Structure

Y040-7904 Chemical Structure

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Y040-7904 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Y040-7904 is a potential mitophagy activator. Y040-7904 enhances mitophagy by promoting mitochondria transport to autophagosomes and the fusion of autophagosomes with autolysosomes. Y040–7904 induces mitophagy through the SIRT1/FoxO3 pathway. Y040-7904 upregulates the levels of Parkin, PINK1, and LC3II/I. Y040-7904 reduces amyloid-β (Aβ) accumulation in both in vitro and in vivo models of Alzheimer’s disease[1].

体外研究
(In Vitro)

Y040-7904 (20 μM, 24 h) 可诱导 HT22 细胞线粒体溶酶体数量显著增加，并使线粒体自噬体 (9%) 和线粒体溶酶体 (18%) 的比例升高，高于两种已确定的线粒体自噬诱导剂 Urolithin A (HY-100599) 和 UMI-77 (HY-18628)[1]。

Y040-7904 (5-20 μM, 24 h) 依赖 SIRT1-FoxO3a 轴促进线粒体自噬相关蛋白 PINK1 和 Parkin 的表达，最终导致 HT22 细胞和 N2a/APPswe 细胞中线粒体自噬水平升高[1]。

Y040-7904 (5-20 μM, 24 h) 通过上调 HT22 细胞中 MFN2、TIM23 和 TOM20 的表达来增强线粒体的生物发生[1]。

Y040-7904 (5-20 μM, 24 h) 减轻N2a/APPswe 细胞中 APP 和 Aβ1-42 的积累[1]。

Y040-7904 (5-20 μM, 24 h) 上调 N2a/APPswe 细胞中 Parkin、PINK1 和 LC3II/I 的水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Y040-7904 相关抗体:

Western Blot Analysis[1]

Cell Line: HT22 cells, PINK1 silenced HT22 cells
Concentration: 5, 10, and 20 μM
Incubation Time: 24 h
Result: Increased the levels of mitophagy-related proteins, including PINK1, Parkin, phosphorylated Ser65-ubiquitin (pUb), and LC3B-II/LC3B–I in a dose- and time-dependent manner in HT22 cells.
Abolished the increase in mitophagy-related proteins, such as pUb and LC3 in PINK1 silenced HT22 cells.
Increased nuclear FoxO3a levels, accompanied by a concomitant decrease in cytoplasmic FoxO3a levels in HT22 cells.
Increased levels of mitochondrial marker MFN2, TIM23, and TOM20 in HT22 cells.

Western Blot Analysis[1]

Cell Line: Neuron-2a cells (N2a/APPswe cells)
Concentration: 5, 10, and 20 μM
Incubation Time: 24 h
Result: Significantly reduced the levels of APP and its C-terminal fragment C99 decreased intracellular Aβ1-42 levels in a dose-dependent manner in N2a/APPswe cells.
Significantly upregulated the levels of f Parkin, PINK1, and LC3II/I in N2a/APPswe cells.

Immunofluorescence[1]

Cell Line: HT22 cells
Concentration: 20 μM
Incubation Time: 24 h
Result: Significantly promoted the nuclear localization of FoxO3a.
体内研究
(In Vivo)

Y040-7904 (500-1000 μM, 96 h) 对减轻 CL4176 和 CL2006 线虫中的阿尔茨海默症具有治疗潜力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Transgenic C. elegans strains CL417647 and CL2006[1].
Dosage: 500, 1000 μM
Administration: 96 h
Result: Resulted in a dose-dependent reduction in Aβ1-42 levels in CL4176 worms.
Decreased the paralysis rate of CL4176 worms (76.2%, 1000 μM), compared to 89.5% in untreated worm at 30 h post temperature upshift.
Reduced paralysis rate of CL2006 worms by 29.3% compared to untreated controls.
分子量

370.35

Formula

C20H18O7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Y040-7904 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Y040-7904PINK1/ParkinMitophagyAmyloid-βPTEN-induced kinase 1/ParkinMitochondrial Autophagyβ-amyloid peptideAβAbetaMitochondriaMitophagosomesMitolysosomesAlzheimer’s disease (AD)Inhibitorinhibitorinhibit

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产品名称：
Y040-7904
目录号：
HY-174806
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