2. GPCR/G Protein
  3. GnRH Receptor
  4. Zoptarelin doxorubicin

Zoptarelin doxorubicin  (Synonyms: AEZS-108; AN-152)

目录号: HY-16532
产品使用指南

摩尔计算器

Zoptarelin doxorubicin (AEZS-108; AN-152) 是一种混合抗癌剂，包括 Zoptarelin 和 Doxorubicin。Zoptarelin doxorubicin 可明显抑制肿瘤进展，在体外诱导细胞凋亡 (apoptosis)。Zoptarelin doxorubicin 已用于靶向 LHRH 受体表达肿瘤的研究。

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Custom Peptide Synthesis

Zoptarelin doxorubicin Chemical Structure

Zoptarelin doxorubicin Chemical Structure

CAS No. : 139570-93-7

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Zoptarelin doxorubicin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro[1].

IC50 & Target

Apoptosis, LHRH receptors[1]
体外研究
(In Vitro)

Zoptarelin doxorubicin (AN-152) inhibits almost 70 % of glioblastoma cell growth, increases almost 250% apoptosis and causes a greater increase in calcein retention[1].
Zoptarelin doxorubicin (AN-152) up-regulates the tumor suppressor and pro-apoptotic p53, and inhibits the expression of the primordial, neuroectodermal stem cell marker, nestin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Zoptarelin doxorubicin 相关抗体:

Cell Proliferation Assay[1]

Cell Line: U-87 MG
Concentration: 100 nM
Incubation Time: 48 h
Result: Brought about an almost 70 % inhibition of tumor cell growth.

Apoptosis Analysis[1]

Cell Line: U-87 MG
Concentration: 100 nM
Incubation Time: 48 h
Result: Increased almost 250 % apoptosis.

Western Blot Analysis[1]

Cell Line: U-87 MG
Concentration: 100 nM
Incubation Time: 24 h
Result: Did not induce any down-regulation of LHRH-R.
Inhibited the expression of the primordial, neuroectodermal stem cell marker, nestin.
Up-regulated the tumor suppressor and pro-apoptotic p53.
体内研究
(In Vivo)

Zoptarelin doxorubicin (AN-152) inhibits tumor growth in glioblastoma xenograft mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice (injected in the flanks with 1×106 glioblastoma U-87 MG cells)[1]
Dosage: 413 nM/20g
Administration: i.v.; once weekly; for 6 weeks
Result: Significantly inhibited tumor growth compared to the control.
Clinical Trial
分子量

1893.01

Formula

C91H117N19O26
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

Zoptarelin doxorubicin 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zoptarelin doxorubicin139570-93-7AEZS-108 AN-152AEZS108AEZS 108AN152AN 152AN-152GnRH ReceptorGonadotropin releasing hormone receptorGNRHRLHRH receptorsanticancerantitumorglioblastomaU-87 MGInhibitorinhibitorinhibit

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