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β-1,3-Glucan  (Synonyms: beta-葡聚糖; β Glucan)

目录号: HY-W145521 含量: 98.18%
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β-1,3-Glucan (β Glucan) is a polysaccharide composed of glucose polymers. β-1,3-Glucan increase the activity of IKKβ kinase, enhances the production of nitric oxide. β-1,3-Glucan improves resistance to Vibrio harveyi infection. β-1,3-Glucan enhances immune response, promotes blood pressure recovery, reduces lung, kidney and liver damage, inhibits the growth of syngeneic tumors.

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β-1,3-Glucan Chemical Structure

β-1,3-Glucan Chemical Structure

CAS No. : 9051-97-2

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

β-1,3-Glucan (β Glucan) is an orally active polysaccharide composed of glucose polymers. β-1,3-Glucan increase the activity of IKKβ kinase, enhances the production of nitric oxide. β-1,3-Glucan improves resistance to Vibrio harveyi infection. β-1,3-Glucan enhances immune response, promotes blood pressure recovery, reduces lung, kidney and liver damage, inhibits the growth of syngeneic tumors[1][2][3][4][5][6][7][8].

IC50 & Target[8]

IKKβ

 

体外研究
(In Vitro)

β-1,3-Glucan (PGG-Glucan;0.1-3 μg/mL;3 h) 能够剂量依赖性地增强白细胞对可溶性和颗粒状激活剂的氧化爆发反应和杀菌活性[1]
β-1,3-Glucan (0.5-5 mg/mL;3 天) 能够显著促进 L-929 成纤维细胞增殖[3]
β-1,3-Glucan 能够增加小鼠单核细胞系 J774a.1 中 IKKβ 激酶的活性,并增强小鼠腹膜巨噬细胞中nitric oxide 和超氧化物的产生[8]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

β-1,3-Glucan (0.09%;添加到饲料中;口服;每日两次;8周) 可促进大黄鱼生长,增强先天免疫力,提高对 Vibrio harveyi 感染的抵抗力[2]
β-1,3-Glucan (40-160 mg/kg;口服;5-10天) 可增强脾细胞对有丝分裂原的增殖反应,增强自然杀伤细胞的活性和腹膜巨噬细胞的溶酶体酶活性,并抑制小鼠同源肿瘤的生长[4]
β-1,3-Glucan (20 mg/kg/天,口服;2 mg/kg/天,皮下注射;口服14天,皮下注射3天) 可促进大鼠内毒血症模型中血压恢复,减轻肾脏和肝脏损伤,并调节细胞因子水平[5]
β-1,3-Glucan (2 mg/kg;肌肉注射;术后立即注射和术后 4 h 注射) 可提高盲肠结扎穿刺 (CLP) 诱发的脓毒症大鼠模型中的存活率,减轻急性肺损伤,抑制促炎细胞因子的释放[6]
β-1,3-Glucan (250-1000 mg/kg;口服;每日一次;18 天) 可预防肿瘤负荷小鼠因肿瘤引起的骨髓抑制和脾肿大[7]
β-1,3-Glucan (150 mg/kg;口服;每日一次;7 天) 可逆转 Aflatoxin B1 (HY-N6615) 介导的免疫抑制,提高雄性成年 Balb/c 小鼠中淋巴细胞亚群的百分比和多种细胞因子的水平[8]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice, 6-8 weeks old, Ehrlich ascites tumour (EAT)-bearing model[7]
Dosage: 250 mg/kg, 500 mg/kg, 1000 mg/kg
Administration: Oral gavage, once a day for 18 days
Result: Significantly prolonged the lifespan of EAT-bearing mice.
Prevented myelosuppression and splenomegaly by increasing the number of granulocyte-macrophage progenitors in the bone marrow and increasing colony-stimulating activity in the serum.
Restored the ability of bone marrow stromal cells from tumor - bearing mice to display myeloid progenitors in long-term bone marrow cultures.
Upregulated the production of interleukin (IL)-6 and IL-1α by these cells.
Restored natural killer cell activity.
Clinical Trial
同用名

beta-葡聚糖; β Glucan

CAS 号
性状

固体

颜色

Off-white to light yellow

中文名称

beta-葡聚糖

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验: 

H2O 中的溶解度 : 40 mg/mL (adjust pH to 12 with 1 M NaOH)

DMSO 中的溶解度 : 5 mg/mL (超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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=
浓度
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体积
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分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
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纯度 & 产品资料

纯度: 98.18%

参考文献
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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