2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Monoamine Transporter Dopamine Transporter
  4. 13-Hydroxyisobakuchiol

13-Hydroxyisobakuchiol  (Synonyms: Delta3,2-Hydroxylbakuchiol)

目录号: HY-N7506
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摩尔计算器

13-Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol) 是从 Psoralea corylifolia 中分离得到，Bakuchiol (HY-N0235) 的类似物。13-Hydroxyisobakuchiol 是一种有效的单胺转运蛋白 (monoamine transporter) 抑制剂，它对多巴胺转运蛋白 (DAT) (IC50=0.58 μM) 和去甲肾上腺素转运蛋白 (NET) (IC50=0.69 μM) 的选择性比血清素转运蛋白 (SERT) (IC50=312.02 μM) 更强。13-Hydroxyisobakuchiol 有潜力用于帕金森病和抑郁症等疾病的研究。

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13-Hydroxyisobakuchiol Chemical Structure

13-Hydroxyisobakuchiol Chemical Structure

CAS No. : 178765-49-6

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13-Hydroxyisobakuchiol 相关抗体

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  • 生物活性

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生物活性

Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) isolated from Psoralea corylifolia (L.), is a potent monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC50=0.58 μM) and norepinephrine transporter (NET) (IC50=0.69 μM) than for the serotonin transporter (SERT) (IC50=312.02 μM). 13-Hydroxyisobakuchiol has the potential for the research of disorders such as Parkinson's disease and depression[1].

IC50 & Target

IC50: 0.58 μM (dopamine transporter)
IC50: 0.69 μM (norepinephrine transporter)[1]
分子量

272.38

Formula

C18H24O2
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

13-Hydroxyisobakuchiol 相关分类

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Keywords:

13-Hydroxyisobakuchiol178765-49-6Delta3,2-HydroxylbakuchiolMonoamine TransporterDopamine TransporterDATSLC6A3monoamine transporterdopamine transporternorepinephrine transporterParkinson's diseasedepressionaddictionInhibitorinhibitorinhibit

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