2. Others Metabolic Enzyme/Protease Cell Cycle/DNA Damage Apoptosis
  3. Isotope-Labeled Compounds Endogenous Metabolite Nucleoside Antimetabolite/Analog Caspase Apoptosis
  4. 2'-Deoxyadenosine-15N5,d13

2'-Deoxyadenosine-15N5,d13 是氘代和 15N 标记的 2'-Deoxyadenosine (HY-W040329)。2′-Deoxyadenosine 是一种腺嘌呤核苷，可抑制葡萄糖刺激的胰岛素释放。2′-Deoxyadenosine 可抑制葡萄糖刺激导致的胰岛环磷酸腺苷 (cAMP) 蓄积增加。2′-Deoxyadenosine 可激活胱天蛋白酶-3 (caspase-3) 并促进细胞凋亡 (apoptosis)。2′-Deoxyadenosine 可抑制 S-腺苷基-L-同型半胱氨酸水解酶 (SAHH) 的活性。2′-Deoxyadenosine 可抑制多种细胞的生长。2′-Deoxyadenosine 对结肠癌有抗癌作用。

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2'-Deoxyadenosine-<sup>15</sup>N<sub>5</sub>,d<sub>13</sub> Chemical Structure

2'-Deoxyadenosine-15N5,d13 Chemical Structure

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Other Forms of 2'-Deoxyadenosine-15N5,d13:

2'-Deoxyadenosine-15N5,d13 相关抗体

Top Publications Citing Use of Products

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2'-Deoxyadenosine-15N5,d13 is deuterium and 15N labeled 2'-Deoxyadenosine (HY-W040329)[1]. 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer[2][3][4].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2'-Deoxyadenosine-15N5,d13 相关抗体:
分子量

269.29

Formula

C10D1315N5O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2'-Deoxyadenosine-15N5,d13 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2'-Deoxyadenosine-15N5,d13Isotope-Labeled CompoundsEndogenous MetaboliteNucleoside Antimetabolite/AnalogCaspaseApoptosisInhibitorinhibitorinhibit

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