2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. 3,4-Dibromo-Mal-PEG4-Acid

3,4-Dibromo-Mal-PEG4-Acid 是一种位点特异性 ADC 连接子，具有二溴马来酰亚胺基团和酸基团。二溴马来酰亚胺基团由于有两个溴原子而允许两个取代点。羧酸可以在 EDC 和 HATU 存在下与一级胺反应形成稳定的酰胺键。亲水性 PEG 接头增加了化合物在水性介质中的水溶性。

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3,4-Dibromo-Mal-PEG4-Acid Chemical Structure

3,4-Dibromo-Mal-PEG4-Acid Chemical Structure

CAS No. : 2434639-17-3

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3,4-Dibromo-Mal-PEG4-Acid 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

生物活性

3,4-Dibromo-Mal-PEG4-acid is a site specific ADC linker with a dibromomaleimide group and an acid group. The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. The carboxylic acid can react with primary amines in the presence of EDC and HATU to form a stable amide bond. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.

分子量

503.14

Formula

C15H21Br2NO8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

3,4-Dibromo-Mal-PEG4-Acid 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

3,4-Dibromo-Mal-PEG4-Acid2434639-17-3ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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