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3-Chloro-5-hydroxybenzoic acid 

目录号: HY-W016868 纯度: 98.01%
COA 产品使用指南

摩尔计算器

3-Chloro-5-hydroxybenzoic acid 是一种有效的、具有口服活性的，选择性乳酸受体 GPR81 激动剂，对人 GPR81 的 EC50 为 16 μM。3-Chloro-5-hydroxybenzoic acid 在肥胖小鼠模型中显示出良好的体内脂肪分解作用。

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3-Chloro-5-hydroxybenzoic acid Chemical Structure

3-Chloro-5-hydroxybenzoic acid Chemical Structure

CAS No. : 53984-36-4

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规格 价格 是否有货 数量
25 mg ￥400
In-stock
50 mg ￥560
In-stock
100 mg ￥720
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

3-Chloro-5-hydroxybenzoic acid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3-Chloro-5-hydroxybenzoic acid is a potent, orally active and selective lactate receptor GPR81 agonist, with an EC50 of 16 μM for human GPR81. 3-Chloro-5-hydroxybenzoic acid exhibits favorable in vivo effects on lipolysis in a mouse model of obesity[1].

体外研究
(In Vitro)

3-Chloro-5-hydroxybenzoic acid shows potency against human (EC50=16 μM), monkey (EC50=17 μM), dog (EC50=67 μM), rat (EC50=7 μM), mouse (EC50=22 μM), and hamster GPR81 (EC50=27 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3-Chloro-5-hydroxybenzoic acid 相关抗体:
体内研究
(In Vivo)

3-Chloro-5-hydroxybenzoic acid (30, 100, and 300 mg/kg; PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks) shows significant reductions in free fatty acids at all doses tested, resulting in a minimum efficacious dose of 30 mg/kg[1].
Pharmacokinetic Parameters of 3-Chloro-5-hydroxybenzoic acid in Mice[1].

dose (mg/kg) tmax (h) AUCinf (h ng/mL) Cmax (ng/mL) Cmax (μM) t1/2 (h)
30 0.5 9356 11689.50 67.2 1.47
100 0.5 51312 55252.80 341.9 1.10

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl6/J mice (DIO mice)[1]
Dosage: 30, 100, and 300 mg/kg
Administration: PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks
Result: Significant reductions in nonesterified free fatty acid cholesterol (NEFAc) at all doses tested.
分子量

172.57

Formula

C7H5ClO3
CAS 号
性状

固体

颜色

White to light brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (579.47 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.7947 mL 28.9737 mL 57.9475 mL
5 mM 1.1589 mL 5.7947 mL 11.5895 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.01%

COA (264 KB) HNMR (129 KB) RP-HPLC (96 KB)

产品使用指南 (1538 KB)
参考文献

3-Chloro-5-hydroxybenzoic acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.7947 mL 28.9737 mL 57.9475 mL 144.8687 mL
5 mM 1.1589 mL 5.7947 mL 11.5895 mL 28.9737 mL
10 mM 0.5795 mL 2.8974 mL 5.7947 mL 14.4869 mL
15 mM 0.3863 mL 1.9316 mL 3.8632 mL 9.6579 mL
20 mM 0.2897 mL 1.4487 mL 2.8974 mL 7.2434 mL
25 mM 0.2318 mL 1.1589 mL 2.3179 mL 5.7947 mL
30 mM 0.1932 mL 0.9658 mL 1.9316 mL 4.8290 mL
40 mM 0.1449 mL 0.7243 mL 1.4487 mL 3.6217 mL
50 mM 0.1159 mL 0.5795 mL 1.1589 mL 2.8974 mL
60 mM 0.0966 mL 0.4829 mL 0.9658 mL 2.4145 mL
80 mM 0.0724 mL 0.3622 mL 0.7243 mL 1.8109 mL
100 mM 0.0579 mL 0.2897 mL 0.5795 mL 1.4487 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Chloro-5-hydroxybenzoic acid53984-36-4Othersnonesterified free fatty acidcholesterolobesitylactate receptorGPR81Inhibitorinhibitorinhibit

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