6-Aminocaproic acid-d₆  (Synonyms: 氨基己酸-d₆; EACA-d₆; Epsilon-Amino-n-caproic acid-d₆; 6-Aminohexanoic acid-d₆)

6-Aminocaproic acid-d₆ is deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

137.21

C₆H₇D₆NO₂

1228656-08-3

固体

White to off-white

6-氨基己酸-d₆；氨基己酸-d₆；氨己酸-d₆

Room temperature in continental US; may vary elsewhere.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. Griffin JD, et, al. Epsilon-aminocaproic acid (EACA). Semin Thromb Hemost. Summer 1978;5(1):27-40.  [Content Brief]

  [3]. Kaye S, et, al. EFFECT OF ε-AMINOCAPROIC ACID ON FIBRINOLYSIS IN PLASMA OF ASIAN ELEPHANTS (ELEPHAS MAXIMUS). J Zoo Wildl Med. 2016 Jun;47(2):397-404.  [Content Brief]

  [4]. Brown JC, et, al. Effect of aminocaproic acid on clot strength and clot lysis of canine blood determined by use of an in vitro model of hyperfibrinolysis. Am J Vet Res. 2016 Nov;77(11):1258-1265.  [Content Brief]