2. MAPK/ERK Pathway
  3. MEK
  4. APS-2-79 hydrochloride

APS-2-79 hydrochloride 是一种 KSR 依赖性的 MEK 拮抗剂。APS-2-79 与 ATPbiotin 竞争性地结合到 KSR2-MEK1 复合物内的 KSR2，IC50 为 120 nM。APS-2-79 与 KSR 结合可将 KSR 固定在一个非活性的状态，使其无法再结合 RAF 和激活 MEK，从而阻断了 Ras-MAPK 信号通路。

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APS-2-79 hydrochloride Chemical Structure

APS-2-79 hydrochloride Chemical Structure

CAS No. : 2002381-31-7

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APS-2-79 hydrochloride 的其他形式现货产品:

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APS-2-79 hydrochloride 相关抗体

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  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

APS-2-79 hydrochloride is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling[1].

IC50 & Target[1]

KSR2

120 nM (IC50)

MEK1

 

体外研究
(In Vitro)

APS-2-79 (5 μM) suppresses KSR-stimulated MEK and ERK phosphorylation in 293H cells[1].
APS-2-79 (1 μM) enhances the efficacy of the clinical MEK inhibitor trametinib within cancer cell lines containing K-Ras mutations[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

APS-2-79 hydrochloride 相关抗体:
分子量

423.89

Formula

C23H22ClN3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Cell Assay
[1]

Cell viability assays are performed in 96 well plates. Optimal cell densities for 96 well plate assays are determined to obtain linear growth over the time course of assays. A549, HCT-116, A375, SK-MEL-239, COLO-205, LOVO, SK-MEL-2, CALU-6, MEWO, SW620 and SW1417 cells are plated at 500 cells per well and treated with inhibitors (e.g., APS-2-79; 100-3,000 nM) for 72hrs before measuring viability. H2087 and HEPG2 cells are plated at 2000 cells per well, and treated with inhibitors (e.g., APS-2-79; 100-3,000 nM) for 72hrs. Cell viability is measured using Resazurin, and the percent cell viability is determined by normalizing inhibitor-treated samples to DMSO controls[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

APS-2-79 hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

APS-2-792002381-31-7MEKMitogen-activated protein kinase kinaseMAPKKMAP2KInhibitorinhibitorinhibit

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产品名称：
APS-2-79 hydrochloride
目录号：
HY-100627A
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