2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR
  4. ATM Inhibitor-1

ATM Inhibitor-1 是一种有效、选择性、可口服的 ATM 抑制剂，IC50 值为 0.7 nM，对 mTOR (IC50，21 μM)，DNAPK (IC50，2.8 μM)，PI3Kα (IC50，3.8 μM)，PI3Kβ (IC50，10.3 μM)，PI3Kγ (IC50，3 μM) 和 PI3Kδ (IC50，0.73 μM) 的作用很弱。ATM Inhibitor-1 具有抗肿瘤活性。

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ATM Inhibitor-1 Chemical Structure

ATM Inhibitor-1 Chemical Structure

CAS No. : 2135639-94-8

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ATM Inhibitor-1 相关抗体

Top Publications Citing Use of Products

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ATM ATR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibitor, with an IC50 of 0.7 nM, shows weak activity against mTOR (IC50, 21 μM), DNAPK (IC50, 2.8 μM), PI3Kα (IC50, 3.8 μM), PI3Kβ (IC50, 10.3 μM), PI3Kγ (IC50, 3 μM) and PI3Kδ (IC50, 0.73 μM). ATM Inhibitor-1 exhibits anti-tumor activity[1].

IC50 & Target[1]

ATM

0.7 nM (IC50)

ATM

2.8 nM (IC50, Cellular assay)

mTOR

21 μM (IC50)

DNAPK

2.8 μM (IC50)

PI3Kα

3.8 μM (IC50)

PI3Kβ

10.3 μM (IC50)

PI3Kγ

3 μM (IC50)

PI3Kδ

0.73 μM (IC50)

体外研究
(In Vitro)

ATM Inhibitor-1 (Compound 21) is a highly potent, selective and orally active ATM Inhibitor, with an IC50 of 0.7 nM, shows weak activity against mTOR (IC50, 21 μM), DNAPK (IC50, 2.8 μM), PI3Kα (IC50, 3.8 μM), PI3Kβ (IC50, 10.3 μM), PI3Kγ (IC50, 3 μM) and PI3Kδ (IC50, 0.73 μM)[1].
In cellular assays, ATM Inhibitor-1 exhibits IC50s of 2.8 nM, >30 μM and >19 μM for ATM, ATR/PI3Kα and PI3Kβ/mTOR, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ATM Inhibitor-1 相关抗体:
体内研究
(In Vivo)

ATM Inhibitor-1 (Compound 21; 50 mg/kg p.o. once daily for 3 days every week starting 24 h post-irinotecan dosing, 21 days) in combination with 50 mg/kg irinotecan significantly reduces tumor growth in SW620 mice model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SW620 mice model[1]
Dosage: 50 mg/kg
Administration: P.O., once daily for 3 days every week starting 24 h post-irinotecan dosing, 21 days
Result: Inhibited the growth of tumor combined with 50 mg/kg irinotecan in SW620 mice model.
分子量

492.61

Formula

C27H36N6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ATM Inhibitor-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATM Inhibitor-12135639-94-8ATM Inhibitor1ATM Inhibitor 1ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedInhibitorinhibitorinhibit

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目录号：
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