2. Immunology/Inflammation Apoptosis Autophagy
  3. PD-1/PD-L1 Apoptosis Autophagy
  4. Atezolizumab

Atezolizumab  (Synonyms: 阿特珠单抗; MPDL3280A)

目录号: HY-P9904 纯度: ≥98.0%
COA

摩尔计算器

Atezolizumab (MPDL3280A) 是一种人源化单克隆抗体 IgG1，抵抗程序性死亡因子配体1 (PD-L1)，用于癌症研究。

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Atezolizumab Chemical Structure

Atezolizumab Chemical Structure

CAS No. : 1380723-44-3

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规格 价格 是否有货 数量
1 mg ￥1900
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5 mg ￥5300
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10 mg ￥8215
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Atezolizumab 相关抗体

Top Publications Citing Use of Products

    Atezolizumab purchased from MCE. Usage Cited in: EJNMMI Res. 2020 Jun 15;10(1):64.  [Abstract]

    Western blot analysis of total cell lysates using anti-PD-L1 (Atezolizumab, 6.91 nM) and anti-β-actin antibody between LoVo, LS174T, SW620, and RKO in vitro.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Atezolizumab (MPDL3280A) is a selective humanized monoclonal IgG1 antibody against programmed death ligand 1 (PD-L1), used for cancer research.

    体外研究
    (In Vitro)

    Atezolizumab (0, 2.5, 5, 10, 20, and 40 µg/ml; 24 hours; HOS and 143B cells) inhibits proliferation and induces immune-independent apoptosis of osteosarcoma cells[1].
    Atezolizumab impairs the function of mitochondria to cause the imbalance between oxidants and antioxidants. Atezolizumab induces mitochondria-related apoptosis of osteosarcoma cells by activating JNK pathway. Atezolizumab (10 µg/ml; 24 hours; HOS and 143B cells) induces autophagy in osteosarcoma cells[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Atezolizumab 相关抗体:
    Clinical Trial
    分子量

    144590.50

    CAS 号
    性状

    液体

    颜色

    Colorless to light yellow

    中文名称

    阿特珠单抗；阿替利珠单抗
    运输条件

    Shipping with dry ice.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料

    纯度: 98.98%

    COA (150 KB)

    抗体抑制剂使用指南 (1152 KB)
    参考文献

    Atezolizumab 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Atezolizumab1380723-44-3MPDL3280A阿特珠单抗阿替利珠单抗PD-1/PD-L1ApoptosisAutophagyPD-1/Programmed death-ligand 1Inhibitorinhibitorinhibit

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