1. Cell Cycle/DNA Damage Cytoskeleton
  2. Microtubule/Tubulin
  3. Cevipabulin fumarate

Cevipabulin fumarate  (Synonyms: TTI-237 fumarate)

目录号: HY-14949C 纯度: 99.97%
COA 产品使用指南

Cevipabulin fumarate (TTI-237 fumarate) 是一种微管活性的、口服有效的抗肿瘤化合物,可抑制 [3H]长春碱与微管蛋白的结合,对人癌细胞的 IC50 值为 18-40 nM。

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Cevipabulin fumarate Chemical Structure

Cevipabulin fumarate Chemical Structure

CAS No. : 849550-67-0

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10 mM * 1ML in DMSO ¥1125
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5 mg ¥880
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10 mg ¥1500
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25 mg ¥3150
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50 mg ¥5040
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100 mg ¥8060
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound and inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line[1][2].

IC50 & Target

IC50: 18-40 nM (microtubule in human tumor cells)[1].

体外研究
(In Vitro)

Cevipabulin (0-50 nM, 72 hours) shows good activity (between 18 and 40 nM IC50 values) on cell lines from ovarian, breast, prostate, and cervical tumors[1].
Flow cytometry experiments reveal that, Cevipabulin (TTI-237) at low concentrations (20-40 nM) produces sub-G1 nuclei and, at concentrations above 50 nM, it causes a strong G2-M block[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: Human cancer cell lines (SK-OV-3, MDA-MB-435, MDA-MB-468, LnCaP, and Hela cells).
Concentration: 0-50 nM
Incubation Time: 72 hours
Result: The IC50 values are 24±8 nM, 21±4 nM, 18±6 nM, 22±7 nM and 40 nM in SK-OV-3, MDA-MB-435, MDA-MB-468, LnCaP and Hela cells.
体内研究
(In Vivo)

Cevipabulin (TTI-2370)( 5, 10, 15, and 20 mg/kg, every 4 days for 4 cycles, in mice) is active by i.v. and p.o. administration against human tumor xenografts, showing dose-dependent effects, with good antitumor activity at 20 and 15 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic nu/nu female mice implanted s.c. in the flank with 1×107 LoVo human colon adenocarcinoma cells[1].
Dosage: 5, 10, 15, and 20 mg/kg
Administration: I.V. injection every 4 days for 4 cycles.
Result: The compound showed dose-dependent effects, with good antitumor activity at 20 and 15 mg/kg.
Animal Model: Athymic nu/nu female mice implanted s.c. in the flank with 1×106 U87-MG human glioblastoma cells[1].
Dosage: 25 mg/kg.
Administration: P.O. or I.V. on days 0, 7, 14.
Result: The compound was active by p.o. or i.v. administration against human tumor xenografts.
Clinical Trial
分子量

580.89

Formula

C22H22ClF5N6O5

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 50 mg/mL (86.07 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

H2O 中的溶解度 : 1.43 mg/mL (2.46 mM; 超声助溶 (<60°C))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7215 mL 8.6075 mL 17.2150 mL
5 mM 0.3443 mL 1.7215 mL 3.4430 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.97%

参考文献

Cevipabulin fumarate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.7215 mL 8.6075 mL 17.2150 mL 43.0374 mL
DMSO 5 mM 0.3443 mL 1.7215 mL 3.4430 mL 8.6075 mL
10 mM 0.1721 mL 0.8607 mL 1.7215 mL 4.3037 mL
15 mM 0.1148 mL 0.5738 mL 1.1477 mL 2.8692 mL
20 mM 0.0861 mL 0.4304 mL 0.8607 mL 2.1519 mL
25 mM 0.0689 mL 0.3443 mL 0.6886 mL 1.7215 mL
30 mM 0.0574 mL 0.2869 mL 0.5738 mL 1.4346 mL
40 mM 0.0430 mL 0.2152 mL 0.4304 mL 1.0759 mL
50 mM 0.0344 mL 0.1721 mL 0.3443 mL 0.8607 mL
60 mM 0.0287 mL 0.1435 mL 0.2869 mL 0.7173 mL
80 mM 0.0215 mL 0.1076 mL 0.2152 mL 0.5380 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Cevipabulin fumarate
目录号:
HY-14949C
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