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  3. Cremophor EL

Cremophor EL  (Synonyms: 聚氧乙烯蓖麻油EL)

目录号: HY-Y1890 含量: 99.52%
COA 产品使用指南

Cremophor EL 是一种聚氧乙烯蓖麻油衍生物,是一种非离子表面活性剂。Cremophor EL 被广泛用于改善活性分子的溶解和输送。

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Cremophor EL Chemical Structure

Cremophor EL Chemical Structure

CAS No. : 61791-12-6

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
100 mL ¥800
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Customer Review

Other Forms of Cremophor EL:

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cremophor EL, a polyoxyethylene castor oil derivative, is a nonionic surfactant. Cremophor EL is widely employed to improve dissolution and delivery of agents[1].

体外研究
(In Vitro)

Cremophor EL is a widely used excipient. In the first 10 h, Cremophor EL at 5 mg/mL increases the impedance, then decreases it, and after 20 h of treatment, epithelial cell death is detected. Cremophor EL decreases cell viability and increases cell toxicity more than RH40. Both epithelial viability and monolayer integrity are seriously impaired at 10 to 50 mg/mL concentrations of Cremophor EL at 24-h treatment. Cremophor EL also enhances cell detachment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAS 号
性状

液体

中文名称

聚氧乙烯蓖麻油EL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

溶解性数据
In Vitro: 

Ethanol 中的溶解度 : 50 mg/mL (超声助溶)

H2O 中的溶解度 : 25 mg/mL (超声助溶)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.52%

参考文献
Cell Assay
[1]

Cell viability is determined by double fluorescent staining: bis-benzimide labels all cell nuclei, ethidium-homodimer-1 stains only dead cells. For morphological examinations, primary brain endothelial cells with tight barrier properties are used. Cells grown on glass coverslips are treated with Cremophor EL and RH40 for 1 and 24 h. Cremophor EL and RH40 are tested at 0.1 to 50 mg/mL concentrations. Triton X-100 detergent (10 mg/mL) is used in toxicity assays as a reference compound to cause cell death[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

Cremophor EL 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Cremophor EL
目录号:
HY-Y1890
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