1. Cytoskeleton
  2. Integrin
  3. GRGDSP

GRGDSP 是一种合成的线性RGD肽,是一种整联蛋白 (integrin) 抑制剂。

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Custom Peptide Synthesis

GRGDSP Chemical Structure

GRGDSP Chemical Structure

CAS No. : 91037-75-1

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2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
1 mg ¥400
In-stock
5 mg ¥1040
In-stock
10 mg ¥1584
In-stock
25 mg ¥2880
In-stock
50 mg ¥4000
In-stock
100 mg ¥5600
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of GRGDSP:

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Top Publications Citing Use of Products

    GRGDSP purchased from MCE. Usage Cited in: Theranostics. 2022; 12(17): 7307-7318

    Immunofluorescence staining images of NeuN and ITGB1 in the peri-infarct area. GRGDSP significantly downregulates rOPN-induced ITGB1.

    GRGDSP purchased from MCE. Usage Cited in: Theranostics. 2022; 12(17): 7307-7318

    GRGDSP decreases the expression of ITGB1 in the peri-infarct area.

    GRGDSP purchased from MCE. Usage Cited in: Theranostics. 2022; 12(17): 7307-7318

    GRGDSP (1 mg/kg; inject at the injured area; single daily for 15 days) apparently reduces the densities of Mpz+, Ki67+and Sox10+ schwann cells in the injured area in the Dhhcre/+;Ninj2fl/fl mice.
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    GRGDSP, a synthetic linear RGD peptide, is an integrin inhibitor.

    IC50 & Target

    Integrin[1]

    体外研究
    (In Vitro)

    It is demonstrated that transarterial infusion of GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro integrin-inhibitor which includes RGD-peptide). As a synthetic linear RGD peptide, GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) can inhibit the adherence of tumor cells to endothelial cells of blood vessels and limit its metastasis[1]. GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) is used as a soluble integrin-blocking RGD-based peptide. GRGDSP is used widely together with other RGD peptides in integrin research. GRGDSP can be used to modify the surface of cardiovascular implants such as vascular grafts to promote endothelialization[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    587.58

    Formula

    C22H37N9O10

    CAS 号
    性状

    固体

    颜色

    White to off-white

    Sequence

    Gly-Arg-Gly-Asp-Ser-Pro

    Sequence Shortening

    GRGDSP

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Sealed storage, away from moisture and light

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    溶解性数据
    In Vitro: 

    H2O 中的溶解度 : 100 mg/mL (170.19 mM; 超声助溶)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.7019 mL 8.5095 mL 17.0190 mL
    5 mM 0.3404 mL 1.7019 mL 3.4038 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

    * 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息:

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    由于实验过程有损耗,建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: 99.91%

    参考文献

    GRGDSP 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.7019 mL 8.5095 mL 17.0190 mL 42.5474 mL
    5 mM 0.3404 mL 1.7019 mL 3.4038 mL 8.5095 mL
    10 mM 0.1702 mL 0.8509 mL 1.7019 mL 4.2547 mL
    15 mM 0.1135 mL 0.5673 mL 1.1346 mL 2.8365 mL
    20 mM 0.0851 mL 0.4255 mL 0.8509 mL 2.1274 mL
    25 mM 0.0681 mL 0.3404 mL 0.6808 mL 1.7019 mL
    30 mM 0.0567 mL 0.2836 mL 0.5673 mL 1.4182 mL
    40 mM 0.0425 mL 0.2127 mL 0.4255 mL 1.0637 mL
    50 mM 0.0340 mL 0.1702 mL 0.3404 mL 0.8509 mL
    60 mM 0.0284 mL 0.1418 mL 0.2836 mL 0.7091 mL
    80 mM 0.0213 mL 0.1064 mL 0.2127 mL 0.5318 mL
    100 mM 0.0170 mL 0.0851 mL 0.1702 mL 0.4255 mL

    * 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Inquiry Information

    产品名称:
    GRGDSP
    目录号:
    HY-P0290
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