1. Cell Cycle/DNA Damage
    PROTAC
  2. CDK
    PROTAC

JH-XI-10-02 

目录号: HY-111518
产品使用指南

JH-XI-10-02 是一种有效、选择性的 CDK8 降解剂,基于 PROTAC 技术,IC50 值为 159 nM。JH-XI-10-02 降解 CDK8 蛋白,但对其 mRNA 水平没有影响。JH-XI-10-02 对 CDK19 无作用。

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JH-XI-10-02 Chemical Structure

JH-XI-10-02 Chemical Structure

CAS No. : 2209085-22-1

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Description

JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19[1].

IC50 & Target[1]

CDK8

159 nM (IC50)

PROTAC

 

References
Molecular Weight

920.14

Formula

C₅₃H₆₉N₅O₉

CAS No.

2209085-22-1

SMILES

O=C(N([C@H]1CC[C@]2(C)C3CC[C@]4(C)[C@@H](C5=CC6=C(C=C5)C=CN=C6)CC[C@@]4([H])[C@]3([H])CCC2C1)C)CCOCCOCCOCCOCCNC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
JH-XI-10-02
目录号:
HY-111518
需求量:

JH-XI-10-02

Cat. No.: HY-111518