LEP(116-130)(mouse)

目录号: HY-P1027 纯度: 98.13%: Data Sheet SDS COA 产品使用指南
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LEP(116-130)(mouse) 是一种合成的瘦素肽片段。

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Custom Peptide Synthesis

LEP(116-130)(mouse) Chemical Structure

CAS No. : 258276-95-8

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规格	价格	是否有货
1 mg	￥800	In-stock
5 mg	￥2400	In-stock
10 mg	￥3900	In-stock
50 mg		询价
100 mg		询价

or 大包装询价

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Customer Review

MCE 顾客使用本产品发表的 1 篇科研文献

•J Int Med Res. 2020 Jun;48(6):300060520920062. [Abstract]

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生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

LEP(116-130)(mouse) is a synthetic leptin peptide fragment.

体外研究
(In Vitro)

LEP-(116-130) (300 μM) is unable to inhibit AP-OB binding^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

LEP-(116-130) (1 mg, i.p.) results in a reduced rate of body weight gain in the presence of increased food intake compared with vehicle-injcted control mice. LEP-(116-130) significantly reduces blood glucose levels by appr 100 mg/dL. Administration of LEP-(116-130) to wild-type (+/+) C57BLKS/J-m mice for 4 or 7 days has no effect on their ability to thermoregulate^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1560.73

Formula

C₆₄H₁₀₉N₁₉O₂₄S

CAS 号

258276-95-8

性状

固体

颜色

White to off-white

Sequence

Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2

Sequence Shortening

SCSLPQTSGLQKPES-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: 98.13%

选择批次：

Data Sheet (515 KB) SDS (252 KB)

COA (287 KB) RP-HPLC (362 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Grasso P, et al. Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor. Diabetes. 1999 Nov;48(11):2204-9. [Content Brief]

Animal Administration ^[1]	Blood is drawn from the tail vein of each mouse 2 h before the onset of the dark period at the beginning of the study (day 0) and after 2, 4, and 6 days of treatment with 1 mg/day i.p. LEP-(116-130). Blood glucose levels are determined with a Glucometer Elite blood glucose monitor. After 4 and 7 days of treatment with 1 mg/day i.p. LEP-(116-130), sensitivity to cold is examined by placing the mice without food or water in a cold room with an ambient temperature of 4°C. Body temperature is measured with a rectal probe every hour for 4 h. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Grasso P, et al. Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor. Diabetes. 1999 Nov;48(11):2204-9. [Content Brief]

Animal Administration
^[1]

Blood is drawn from the tail vein of each mouse 2 h before the onset of the dark period at the beginning of the study (day 0) and after 2, 4, and 6 days of treatment with 1 mg/day i.p. LEP-(116-130). Blood glucose levels are determined with a Glucometer Elite blood glucose monitor. After 4 and 7 days of treatment with 1 mg/day i.p. LEP-(116-130), sensitivity to cold is examined by placing the mice without food or water in a cold room with an ambient temperature of 4°C. Body temperature is measured with a rectal probe every hour for 4 h.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Grasso P, et al. Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor. Diabetes. 1999 Nov;48(11):2204-9. [Content Brief]

LEP(116-130)(mouse) 相关分类

Others

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LEP(116-130)(mouse)258276-95-8OthersInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LEP(116-130)(mouse)

Customer Review

MCE 顾客使用本产品发表的 1 篇科研文献