2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. MCHR1 (GPR24) Cytochrome P450
  4. MCH-1 antagonist 1

MCH-1 antagonist 1 是一种有效的黑色素浓缩激素 1 (MCH-1) 拮抗剂，Ki 值为 2.6 nM。MCH-1 antagonist 1 还抑制 CYP3A4，IC50 为 10 μM。

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MCH-1 antagonist 1 Chemical Structure

MCH-1 antagonist 1 Chemical Structure

CAS No. : 1039825-68-7

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MCH-1 antagonist 1 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC50 of 10 μM.

IC50 & Target

CYP3A4

10 μM (IC50)

MCH-1

2.6 nM (Ki)

体外研究
(In Vitro)

MCH-1 antagonist 1 (Compound 1) also inhibits cytochrome P450 3A4 (CYP3A4) with an IC50 of 10 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MCH-1 antagonist 1 相关抗体:
体内研究
(In Vivo)

MCH-1 antagonist 1 is administered to male C57BL/6J DIO mice to assess their pharmacokinetic profile. Effect of MCH-1 antagonist 1 (dosed at 30 mg/kg, po) is measured on the body weight of DIO mice with the AUC0-6 h of 14760 h*ng/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

414.50

Formula

C25H26N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MCH-1 antagonist 1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MCH-1 antagonist 11039825-68-7MCHR1 (GPR24)Cytochrome P450Melanin concentrating hormone receptor 1CYPsInhibitorinhibitorinhibit

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产品名称：
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目录号：
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