1. Metabolic Enzyme/Protease
    NF-κB
  2. MALT1
  3. MLT-748

MLT-748 

目录号: HY-115466
产品使用指南

MLT-748 是一种有效、选择性的 MALT1 的别构抑制剂,与 MALT1 的别构 Trp580 口袋结合,IC50 值为 5 nM。

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MLT-748 Chemical Structure

MLT-748 Chemical Structure

CAS No. : 1832578-30-9

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Description

MLT-748 is a potent, selective and allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5 nM[1].

IC50 & Target

IC50: 5 nM (MALT1)[1]
Kd: 13 nM (MALT1(329-728)-W580S), 42 nM (MALT1(329-728))[1]

In Vitro

MLT-748 reversibly binds to human mutant MALT1(329-728)-W580S (Kd, 13 nM) with affinity similar to that of the wild type MALT1(329-728) (Kd, 42 nM)[1].
MLT-748 (0-2 μM) stabilizes cellular MALT1-W580S, with an EC50 of 69 nM[1].
MLT-748 (2 µM, 24 hours) increases the phosphorylation of p65 and IκBα in MALT1mut/mut patient immortalized B cells[1].

Western Blot Analysis

Cell Line: MALT1mut/mut patient immortalized B cells
Concentration: 2 µM
Incubation Time: 24 hours
Result: Increased NF-κB signaling phosphorylation of both p65 and IκBα as early as 5 min after stimulation with PMA and ionomycin.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

492.32

Formula

C₁₉H₁₉Cl₂N₉O₃

CAS No.

1832578-30-9

SMILES

O=C(NC1=CC(Cl)=C(N2N=CC=N2)N=C1)NC3=C([C@@H](OC)[C@H](OC)C)N4C(N=C3)=CC(Cl)=N4

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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产品名称:
MLT-748
目录号:
HY-115466
需求量:

MLT-748

Cat. No.: HY-115466