1. Metabolic Enzyme/Protease
    NF-κB
  2. MALT1

MLT-748 

目录号: HY-115466
产品使用指南

MLT-748 是一种 MALT1 的别构抑制剂,与 MALT1 的别构 Trp580 口袋结合,IC50 值为 5 nM。MLT-748 不可逆地与人突变型 MALT1(329-728)-W580S 和野生型 MALT1(329-728) 结合,Kd 值分别为 13 nM 和 42 nM。

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MLT-748 Chemical Structure

MLT-748 Chemical Structure

CAS No. : 1832578-30-9

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Description

MLT-748 is an allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5 nM. MLT-748 also reversibly binds to human mutant MALT1(329-728)-W580S (Kd, 13 nM) with affinity similar to that of the wild type MALT1(329-728) (Kd, 42 nM)[1].

IC50 & Target

IC50: 5 nM (MALT1)[1]
Kd: 13 nM (MALT1(329-728)-W580S), 42 nM (MALT1(329-728))[1]

References
Molecular Weight

492.32

Formula

C₁₉H₁₉Cl₂N₉O₃

CAS No.

1832578-30-9

SMILES

O=C(NC1=CC(Cl)=C(N2N=CC=N2)N=C1)NC3=C([C@@H](OC)[C@H](OC)C)N4C(N=C3)=CC(Cl)=N4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
MLT-748
目录号:
HY-115466
需求量:

MLT-748

Cat. No.: HY-115466