1. Metabolic Enzyme/Protease
  2. Acyltransferase
  3. Nevanimibe

Nevanimibe (Synonyms: PD-132301; ATR-101)

目录号: HY-100399
产品使用指南

Nevanimibe (PD-132301; ATR101) 是一种有效的选择性酰基辅酶 A:胆固醇 O-酰基转移酶 1 (ACAT1) 抑制剂,EC50 为 9 nM。Nevanimibe (PD-132301; ATR101) 抑制 ACAT2,EC50 为 368 nM。

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Nevanimibe Chemical Structure

Nevanimibe Chemical Structure

CAS No. : 133825-80-6

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Nevanimibe 的其他形式现货产品:

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Description

Nevanimibe (PD-132301; ATR101) is a selective and potent acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe (PD-132301; ATR101) inhibits ACAT2 with an EC50 of 368 nM[1].

IC50 & Target[1]

ACAT1

9 nM (EC50)

ACAT2

368 nM (EC50)

In Vitro

Coincubation of Nevanimibe (ATR-101; 3 nM-30 μM) and Cholesterol markedly increases toxicity in a dose-dependent manner, where 3 nM Nevanimibe in the presence of 60 μg/mL Cholesterol reduces survival by 60% after 24 hours. All doses of Nevanimibe (3 nM-30 μM) induces cytoxicity in the presence of Cholesterol, whereas treatment with Cholesterol in the absence of Nevanimibe has no effect on cell viability[1].

Cell Cytotoxicity Assay[1]

Cell Line: The H295R and HAC clone 15 (HAC15) human ACC cell lines
Concentration: 3 nM-30 μM
Incubation Time: 24 hours
Result: 3 nM-3 μM exhibited no toxicity, whereas 30 μM treatment reduced survival by approximately 40% within 24 hours.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

421.62

Formula

C₂₇H₃₉N₃O

CAS No.

133825-80-6

SMILES

O=C(NCC1(C2=CC=C(N(C)C)C=C2)CCCC1)NC3=C(C(C)C)C=CC=C3C(C)C

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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产品名称:
Nevanimibe
目录号:
HY-100399
需求量:

Nevanimibe

Cat. No.: HY-100399