1. Metabolic Enzyme/Protease
  2. ROR

PF-06747711 

目录号: HY-112706
产品使用指南

PF-06747711 是一种有效、选择性、可口服的视黄酸受体相关孤儿受体 C2 (RORC2RORγt) 的反向激动剂,IC50 值为 4.1 nM。具有抗皮肤炎的功效。

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PF-06747711 Chemical Structure

PF-06747711 Chemical Structure

CAS No. : 1892576-58-7

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Description

PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. Anti-skin inflammatory activity[1].

IC50 & Target

IC50: 4.1 nM (RORC2)[1]

In Vitro

PF-06747711 (Compound 66) reduces IL-17 production by human Th17 cells with an IC50 of 9.5 nM[1].

References
Molecular Weight

497.51

Formula

C₂₆H₂₆F₃N₅O₂

CAS No.

1892576-58-7

SMILES

O=C(NC1=CN=C(N(C)C=C2C3CCN(C(C(C)C)=O)CC3)C2=C1C(F)(F)F)C4=CC=CC(C#N)=C4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
PF-06747711
目录号:
HY-112706
需求量:

PF-06747711

Cat. No.: HY-112706