1. Anti-infection
  2. Bacterial

Polymyxin B nonapeptide 

目录号: HY-106783
产品使用指南

Polymyxin B nonapeptide 是一种阳离子环肽。Polymyxin B nonapeptide 是经酶裂解 Polymyxin B 而产生的衍生物,与 Polymyxin B 相比,Polymyxin B nonapeptide 毒性低,缺乏杀菌活性,仍具有破坏革兰氏阴性菌外膜的能力。

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Custom Peptide Synthesis

Polymyxin B nonapeptide Chemical Structure

Polymyxin B nonapeptide Chemical Structure

CAS No. : 86408-36-8

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥2649 In-stock
5 mg ¥1500 In-stock
10 mg ¥2500 In-stock
50 mg ¥9500 In-stock
100 mg ¥16500 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue[1]. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes[2].

In Vitro

Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probably by binding to the bacterial lipopolysaccharide (LPS)[1].

References
Molecular Weight

963.13

Formula

C₄₃H₇₄N₁₄O₁₁

CAS No.

86408-36-8

Sequence

Thr-{Dab}-{Dab}-{Dab}-{Dab}-d-Phe-Leu-{Dab}-{Dab}-Thr (Lactam: Dab3-Thr9)

Sequence Shortening

T-{Dab}-{Dab}-{Dab}-{Dab}-d-FL-{Dab}-{Dab}-T (Lactam: Dab3-Thr9)

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Polymyxin B nonapeptide
目录号:
HY-106783
需求量:

Polymyxin B nonapeptide

Cat. No.: HY-106783