2. Protein Tyrosine Kinase/RTK
  3. Btk
  4. RN486

RN486 是一种有效的，选择性的，具有口服活性的 Btk 抑制剂，IC50 为 4.0 nM，Kd 为 0.31 nM，对其他激酶的活性较低。RN486 可用于类风湿关节炎和系统性红斑狼疮的研究。

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RN486 Chemical Structure

RN486 Chemical Structure

CAS No. : 1242156-23-5

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1740
In-stock
1 mg ￥679
In-stock
5 mg ￥1300
In-stock
10 mg ￥2100
In-stock
25 mg ￥4200
In-stock
50 mg ￥6700
In-stock
100 mg ￥10000
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

RN486 相关抗体

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Top Publications Citing Use of Products

    RN486 purchased from MCE. Usage Cited in: Blood Adv. 2020 Jun 9;4(11):2439-2450.  [Abstract]

    Western blot on whole-cell lysates from B cells with indicated genotype (wild-type or C481S), inhibitor treatment (ibrutinib or RN486) and stimulation (anti-IgM and H2O2).

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    RN486 is a potent, selective and orally active Btk inhibitor with an IC50 of 4.0 nM and a Kd of 0.31 nM. RN486 is less active for other kinases. RN486 can be used for rheumatoid arthritis and systemic lupus erythematosus research[1][2][3].

    IC50 & Target

    IC50: 4.0 nM (Btk)[1]
    Kd: 0.31 nM (Btk)[1]
    体外研究
    (In Vitro)

    RN486 blocks Fcε receptor cross-linking-induced degranulation in mast cells (IC50 = 2.9 nM), Fcγ receptor engagement-mediated tumor necrosis factor α production in monocytes (IC50 = 7 nM), and B cell antigen receptor-induced expression of an activation marker, CD69, in B cells in whole blood (IC50 = 21 nM)[1].
    In a co-culture system consisting of human primary synovial FLS and activated human platelets, convulxin stimulation resulted in elevated production of pro-inflammatory cytokines, IL-6 and IL-8, an effect which is dose-dependently blocked by RN486[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    RN486 相关抗体:
    体内研究
    (In Vivo)

    RN486 produces robust anti-inflammatory and bone-protective effects in mouse CIA and rat adjuvant-induced arthritis (AIA) models. In the AIA model, RN486 (1-30 mg/kg) inhibits both joint and systemic inflammation, reducing both paw swelling and inflammatory markers in the blood[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    606.69

    Formula

    C35H35FN6O3
    CAS 号
    性状

    固体

    颜色

    Off-white to light yellow

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    溶解性数据
    In Vitro: 

    DMSO 中的溶解度 : 24 mg/mL (39.56 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.6483 mL 8.2414 mL 16.4829 mL
    5 mM 0.3297 mL 1.6483 mL 3.2966 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料

    纯度: 99.87%

    COA (190 KB) HNMR (326 KB) LCMS (122 KB)

    产品使用指南 (1538 KB)
    参考文献

    RN486 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.6483 mL 8.2414 mL 16.4829 mL 41.2072 mL
    5 mM 0.3297 mL 1.6483 mL 3.2966 mL 8.2414 mL
    10 mM 0.1648 mL 0.8241 mL 1.6483 mL 4.1207 mL
    15 mM 0.1099 mL 0.5494 mL 1.0989 mL 2.7471 mL
    20 mM 0.0824 mL 0.4121 mL 0.8241 mL 2.0604 mL
    25 mM 0.0659 mL 0.3297 mL 0.6593 mL 1.6483 mL
    30 mM 0.0549 mL 0.2747 mL 0.5494 mL 1.3736 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    RN4861242156-23-5RN 486RN-486BtkBruton tyrosine kinaseInhibitorinhibitorinhibit

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    目录号：
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