1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)

Angiotensin-converting Enzyme (ACE)

Angiotensin-converting enzyme (ACE) indirectly increases blood pressure by causing blood vessels to constrict. ACE does that by converting angiotensin I to angiotensin II, which constricts the vessels. ACE, angiotensin I and angiotensin II are part of the renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. ACE is secreted in the lungs and kidneys by cells in the endothelium (inner layer) of blood vessels. It has two primary functions: ACE catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor in a substrate concentration-dependent manner. ACE degrades bradykinin, a potent vasodilator, and other vasoactive peptides. These two actions make ACE inhibition a goal in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy, and type 2 diabetes mellitus. Inhibition of ACE (by ACE inhibitors) results in the decreased formation of angiotensin II and decreased metabolism of bradykinin, leading to systematic dilation of the arteries and veins and a decrease in arterial blood pressure.

Angiotensin-converting Enzyme (ACE) 相关产品 (33):

Cat. No. Product Name Effect Purity
  • HY-12403
    Angiotensin 1-7 Inhibitor 98.62%
    Angiotensin (1-7) 抑制纯化的犬血管紧张素转换酶 (ACE) 活性,IC50 为 0.65 μM。
  • HY-B0368
    Captopril Inhibitor 98.05%
    Captopril是血管紧张素转化酶(ACE)抑制剂。
  • HY-18206A
    Lisinopril dihydrate Inhibitor 99.34%
    Lisinopril二水合物是血管紧张素转化酶抑制剂,可作用于高血压,充血性心力衰竭和心脏病等。
  • HY-B0093A
    Benazepril hydrochloride Inhibitor 99.99%
    Benazepril盐酸盐是血管紧张素转化酶(ACE)抑制剂,可作用于高血压。
  • HY-B0331A
    Enalapril maleate Inhibitor 98.14%
    Enalapril马来酸盐是enalapril的活性代谢物,是血管紧张素转化酶(ACE)抑制剂。
  • HY-18208
    Omapatrilat Inhibitor
    Omapatrilat是金属蛋白酶ACENEP的双重抑制剂,Ki值分别为0.64和0.45 nM。
  • HY-P0143
    Leucylarginylproline Inhibitor
    Leucylarginylproline是血管紧张素转换酶 (ACE) 抑制剂,IC50值为0.27μM。
  • HY-N2021A
    Phosphoramidon Disodium Inhibitor >98.0%
    Phosphoramidon disodium 是金属蛋白酶 ( metalloprotease ) 抑制剂 。抑制内皮素转化酶 ( ECE ) ,中性肽内切酶 ( NEP ) 和血管紧张素转换酶 ( ACE ) 的IC50 值分别为 3.5 ,0.034 和 78 μM。
  • HY-A0043A
    Cilazapril monohydrate Inhibitor 98.63%
    Cilazapril一水合物是血管紧张素转化酶抑制剂,可作用于高血压和充血性心力衰竭。
  • HY-B0130A
    Perindopril erbumine Inhibitor 99.90%
    Perindopril是长效血管紧张素转换酶(ACE)抑制剂。
  • HY-B0231
    Enalaprilat dihydrate Inhibitor
    Enalaprilat是血管紧张素转化酶(ACE)抑制剂,IC50为1.94 nM。
  • HY-B0384
    Temocapril hydrochloride Inhibitor
    Temocapril盐酸盐是长效血管紧张素转换酶(ACE)抑制剂,可作用于高血压。
  • HY-B0655
    Zofenopril calcium Inhibitor
    Zofenopril Calcium(SQ26991)是抗氧化剂和血管紧张素转化酶(ACE)抑制剂。
  • HY-B0378A
    Moexipril hydrochloride Inhibitor
    Moexipril盐酸盐是口服活性的不含巯基的血管紧张素转化酶抑制剂,可作用于高血压和充血性心力衰竭。
  • HY-B0279
    Ramipril Inhibitor
    Ramipril是ACE抑制剂,IC50为5 nM。
  • HY-B0477
    Quinapril hydrochloride Inhibitor 99.46%
    Quinapril盐酸盐是血管紧张素转化酶(ACE)抑制剂的原药。
  • HY-A0043
    Cilazapril Inhibitor
    Cilazapril是血管紧张素转化酶(ACE)抑制剂,可作用于高血压和充血性心力衰竭。
  • HY-B1451
    Imidapril hydrochloride Inhibitor
    Imidapril盐酸盐是血管紧张素转换酶 (ACE) 抑制剂,具有抗高血压活性。
  • HY-B0231AS
    Enalaprilat D5 Inhibitor
    Enalaprilat D5是Enalaprilat的氘代化合物标准品。
  • HY-B0382
    Fosinopril sodium Inhibitor >98.0%
    Fosinopril钠是血管紧张素转换酶(ACE)抑制剂的原药,可作用于高血压和慢性心力衰竭。