1. GPCR/G Protein
    Immunology/Inflammation
  2. CCR

CCR6 inhibitor 1 

目录号: HY-112701 纯度: 99.82%
产品使用指南

CCR6 inhibitor 1 是一种有效、选择性的 CCR6 抑制剂,对猴子和人 CCR6 的 IC50 值分别为 0.45 和 6 nM,对其选择性远高于人 CCR1 (IC50,> 30000 nM) 和 CCR7 (IC50,9400 nM)。CCR6 inhibitor 1 显著抑制 ERK 磷酸化。可用于自身免疫病和癌症的研究。

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CCR6 inhibitor 1 Chemical Structure

CCR6 inhibitor 1 Chemical Structure

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥4995 In-stock
5 mg ¥4500 In-stock
10 mg ¥7500 In-stock
50 mg ¥19500 In-stock
100 mg ¥33000 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000 nM), and CCR7 (IC50, 9400 nM). CCR6 inhibitor 1 markedly blocks ERK phosphorylation. CCR6 inhibitor 1 is used in the research of autoimmune diseases and cancer[1].

IC50 & Target[1]

Moneky CCR6

0.45 nM (IC50)

Human CCR6

6 nM (IC50)

Human CCR7

9400 nM (IC50)

In Vitro

CCR6 inhibitor 1 (Compound 35) inhibits L20-induced human B cell migration[1].

References
Molecular Weight

504.52

Formula

C₂₄H₂₃F₃N₄O₃S

SMILES

O=S([C@H](CC1)CC[C@@H]1NC2=NC=C(C(F)(F)F)C=C2)(C3=CC=C(C4=CC=NC(C(N)=O)=C4)C=C3)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
CCR6 inhibitor 1
目录号:
HY-112701
需求量:

CCR6 inhibitor 1

Cat. No.: HY-112701