1. Metabolic Enzyme/Protease
  2. Enolase

Enolase

Enolase (phosphopyruvate hydratase) is a metalloenzyme responsible for the catalysis of the conversion of 2-phosphoglycerate (2-PG) tophosphoenolpyruvate (PEP), the ninth and penultimate step of glycolysis. Enolase belongs to the class Lyase. Enolase can also catalyze the reverse reaction, depending on environmental concentrations of substrates. The optimum pH for this enzyme is 6.5. Enolase is present in all tissues and organisms capable of glycolysis or fermentation. Small-molecule inhibitors of enolase have been synthesized as chemical probes of the catalytic mechanism of the enzyme. The most potent of inhibitors is phosphonoacetohydroxamate, which in its unprotonated form has pM affinity for the enzyme. It has structural similarity to the presumed catalytic intermediate, between PEP and 2-PG. Attempts have been made to use this inhibitor as an anti-trypanosome drug, and more recently, as an anti-cancer agent.

Enolase 相关产品 (2):

Cat. No. Product Name Effect Purity
  • HY-15858A
    AP-III-a4 hydrochloride Inhibitor >98.0%
    ENOblock(AP-III-a4)盐酸盐能直接与烯醇酶结合,IC50为576nM,还能抑制体内癌细胞转移。
  • HY-15858
    AP-III-a4 Inhibitor
    ENOblock(AP-III-a4)是第一个非底物类似物,可直接与烯醇酶结合,IC50为0.576 uM,能抑制体内癌细胞转移。
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