1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor

GABA Receptor

GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known asmetabotropic receptors). It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel. This channel was subsequently termed the GABAA receptor. Fast-responding GABA receptors are members of family of Cys-loop ligand-gated ion channels. A slow response to GABA is mediated by GABAB receptors, originally defined on the basis of pharmacological properties.

GABA Receptor 相关产品 (58):

Cat. No. Product Name Effect Purity
  • HY-N0219
    (+)-Bicuculline Antagonist 99.92%
    比枯枯灵 (Bicucullin),一种生物碱,是GABA的拮抗剂。
  • HY-15399
    Vigabatrin Inhibitor >98.0%
    Vigabatrin盐酸盐(γ-Vinyl-GABA; Sabril)是GABA的结构类似物,能不可逆地抑制GABA氨基转移酶对GABA的分解代谢。
  • HY-17441
    Zolpidem 99.86%
    Zolpideman(SL 800750)是神经递质抑制剂,能结合GABAA受体上benzodiazepines的结合位点,EC50为75 nM。
  • HY-B0007
    Baclofen Agonist 99.44%
    Baclofen是GABA衍生物,可松弛骨骼肌肉。
  • HY-17354
    (R)-Baclofen Agonist
    (R)-Baclofen(STX209)是选择性GABAB受体激动剂。
  • HY-B0799
    Dihydroergotoxine mesylate Modulator >98.0%
    Dihydroergotoxine mesylate是系列生物碱盐混合物,对GABAA受体高结合活性。
  • HY-16716
    Basmisanil Inhibitor 99.65%
    Basmisanil 是一种高度选择性的 GABAAα5 的负调节剂。
  • HY-18995
    Indiplon Agonist 98.02%
    Indiplon是一种强效GABAA受体正变构调节剂, 作用于苯并二氮位点 (作用于大鼠额皮质和小脑,Ki值分别是1.2和1.7nM)。
  • HY-11048
    NS11394 Activator
    NS11394是GABA(A)受体高效调节剂,对alpha(5)亚类活性最高。
  • HY-B0741
    Zopiclone Agonist
    Zopiclone(RP27267)是可作用于失眠的非苯二氮类化合物。
  • HY-14265
    Zaleplon 99.49%
    Zaleplon(CL-284846)可作用于失眠症,短效。
  • HY-B0100
    Etomidate Agonist 99.21%
    Etomidate(R-16659)是GABAA受体激动剂。
  • HY-B0355
    Ginkgolide A Antagonist >98.0%
    Ginkgolide A提取自银杏叶,是GABA拮抗剂。
  • HY-B0009
    Flumazenil Antagonist
    Flumazenil 是一种有竞争性的 GABAA receptor 拮抗剂,用于治疗苯二氮类药物过量问题。
  • HY-B1122
    L-Cycloserine Inhibitor
    L-cycloserine作用于大肠杆菌和各种动物大脑, 不可逆地抑制GABA 5'-磷酸吡哆醛氨基转移酶, 这种作用具有时间依赖性, 导致了γ-氨基丁酸 (GABA) 含量增高, GABA在体内抑制性神经递质。
  • HY-19371
    Lorediplon Modulator
    Lorediplon是一种新型非苯并二氮卓类, 是一种催眠药, 充当GABA A受体调节剂。
  • HY-B0837
    Emamectin Benzoate Activator
    Emamectin Benzoate通过与GABA受体结合, 而激活氯离子通道和谷氨酸门控氯离子通道, 从而干扰节肢动物神经信号。
  • HY-B0696A
    Tiagabine hydrochloride Inhibitor 98.20%
    Tiagabine(NO328)盐酸盐是GABA重吸收抑制剂。
  • HY-100140
    Pipequaline Agonist 98.61%
    Pipequaline (PK 8165)是benzodiazepine受体的部分激动剂,具有抗焦虑活性。
  • HY-101665
    Pagoclone Agonist >98.0%
    Pagoclone是有活性的(+)-RP59037,为GABA(A) receptor的局部激活剂,常用于治疗恐慌和焦虑等疾病。