1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor

GABA Receptor

GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known asmetabotropic receptors). It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel. This channel was subsequently termed the GABAA receptor. Fast-responding GABA receptors are members of family of Cys-loop ligand-gated ion channels. A slow response to GABA is mediated by GABAB receptors, originally defined on the basis of pharmacological properties.

GABA Receptor 相关产品 (82):

Cat. No. Product Name Effect Purity
  • HY-N0219
    (+)-Bicuculline Antagonist 99.93%
    比枯枯灵 (Bicucullin),一种生物碱,是GABA的拮抗剂。
  • HY-B0211
    Riluzole Inhibitor 99.83%
    Riluzole 是一种抗惊厥药物,属于依赖于使用的钠通道阻滞剂家族,它也可以抑制 GABA 摄取,其 IC50 值为 43 μM。
  • HY-15399
    Vigabatrin Inhibitor >98.0%
    Vigabatrin盐酸盐(γ-Vinyl-GABA; Sabril)是GABA的结构类似物,能不可逆地抑制GABA氨基转移酶对GABA的分解代谢。
  • HY-B0007
    Baclofen Agonist 98.21%
    Baclofen是GABA衍生物,可松弛骨骼肌肉。
  • HY-B1122
    L-Cycloserine Inhibitor 99.52%
    L-cycloserine作用于大肠杆菌和各种动物大脑, 不可逆地抑制GABA 5'-磷酸吡哆醛氨基转移酶, 这种作用具有时间依赖性, 导致了γ-氨基丁酸 (GABA) 含量增高, GABA在体内抑制性神经递质。
  • HY-103040
    SAGE-217 Agonist 99.93%
    SAGE-217 是一个有效的 GABAA 受体激动剂, 对 α1β2γ2α4β3δ GABAA 受体的 EC50 值分别为 296 和 163 nM。
  • HY-107994
    Aminooxyacetic acid hemihydrochloride Inhibitor >98.0%
    Aminooxyacetic acid hemihydrochloride 是苹果酸-天冬氨酸穿梭 (MAS) 抑制剂, 也能抑制 GABA 降解酶 GABA-T
  • HY-B0211A
    Riluzole hydrochloride Inhibitor 99.94%
    Riluzole hydrochloride 是一种抗惊厥药物,属于依赖于使用的钠通道阻滞剂家族,它也可以抑制 GABA 摄取,其 IC50 值为 43 μM。
  • HY-B0677
    Etizolam 99.89%
    Etizolam(AHR3219; Y7131)是苯二氮类似物。
  • HY-17354
    (R)-Baclofen Agonist >98.0%
    (R)-Baclofen(STX209)是选择性GABAB受体激动剂。
  • HY-101391
    Picrotoxin Antagonist >98.0%
    Picrotoxin 是一种非竞争性的 GABAA receptor 拮抗剂。
  • HY-B0100
    Etomidate Agonist 99.33%
    Etomidate(R-16659)是GABAA受体激动剂。
  • HY-11048
    NS11394 Activator 99.01%
    NS11394是GABA(A)受体高效调节剂,对alpha(5)亚类活性最高。
  • HY-16579A
    Etifoxine Activator 99.94%
    Etifoxine(HOE 36-801)是GABAA受体增强剂,倾向作用于含β2或β3亚基的GABAA受体。
  • HY-16716
    Basmisanil Inhibitor 99.65%
    Basmisanil 是一种高度选择性的 GABAAα5 的负调节剂。
  • HY-B0799
    Dihydroergotoxine mesylate Modulator >98.0%
    Dihydroergotoxine mesylate是系列生物碱盐混合物,对GABAA受体高结合活性。
  • HY-100140
    Pipequaline Agonist 98.61%
    Pipequaline (PK 8165) 是非选择性的 GABAA 受体部分激动剂,具有抗焦虑活性。
  • HY-17030
    Acamprosate calcium Agonist 98.13%
    Acamprosate calcium(Campral EC)是GABA受体激动剂和谷氨酸能系统调节剂。
  • HY-B0355
    Ginkgolide A Antagonist >98.0%
    Ginkgolide A提取自银杏叶,是GABA拮抗剂。
  • HY-B1242
    Pentylenetetrazol Antagonist 99.80%
    Pentylenetetrazol是GABA(A)受体拮抗剂, 建立诱导癫痫模型。