1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. HMG-CoA Reductase (HMGCR)

HMG-CoA Reductase (HMGCR)

HMG-CoA Reductase (HMGCR) is the rate-controlling enzyme of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor as well as oxidized species of cholesterol. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. HMG-CoA reductase is thus the target of the widely available cholesterol-lowering drugs known collectively as the statins. HMG-CoA reductase is anchored in the membrane of the endoplasmic reticulum, and was long regarded as having seven transmembrane domains, with the active site located in a long carboxyl terminal domain in the cytosol.

HMG-CoA Reductase (HMGCR) 相关产品 (23):

Cat. No. Product Name Effect Purity
  • HY-17502
    Simvastatin Inhibitor >98.0%
    Simvastatin 是一种竞争性的 HMG-CoA reductase 抑制剂,Ki 值为 0.2 nM。
  • HY-N0504
    Lovastatin Inhibitor 99.47%
    Lovastatin是一种用于降低胆固醇的细胞渗透性的 HMG-CoA还原酶抑制剂。
  • HY-17379
    Atorvastatin hemicalcium salt Inhibitor 99.98%
    Atorvastatin hemicalcium salt 是有效的 HMG-CoA 还原酶抑制剂,IC50 值为 8 nM。
  • HY-17504
    Rosuvastatin Calcium Inhibitor
    Rosuvastatin钙盐是HMG-CoA还原酶抑制剂,IC50为11 nM。
  • HY-B0144
    Pitavastatin Calcium Inhibitor 99.94%
    Pitavastatin Calcium是有效的羟甲基戊二酰-CoA (HMG-CoA) 还原酶抑制剂。Pitavastatin Calcium在HepG2细胞中抑制乙酸合成胆固醇的 IC50 为5.8 nM。
  • HY-114316
    HMG499 Inhibitor
    HMG499是有效,选择性的 HMG-CoA还原酶 抑制剂, EC50为 0.41 μM。HMG499可预防他汀类药物诱导的HMGCR积聚,降低血清胆固醇水平,减少动脉粥样硬化。
  • HY-14664A
    Fluvastatin sodium Inhibitor >98.0%
    Fluvastatin (XU 62320) 钠是HMG-CoA还原酶竞争性抑制剂。
  • HY-17408
    Mevastatin Inhibitor 98.45%
    Mevastatin (Compactin; ML236B)抑制HMG-CoA还原酶(HMGCR),可抑制类异戊二烯的生物合成,阻断蛋白的异戊二烯化,降低血浆胆固醇水平。
  • HY-B0165A
    Pravastatin sodium Inhibitor 99.32%
    Pravastatin (sodium) (CS-514 (sodium)) 是 HMG-CoA 还原酶抑制剂,对甾醇合成的 IC50 为 5.6 μM。
  • HY-17640
    Nicodicosapent Inhibitor 98.19%
    Nicodicosapent 是一种脂肪酸烟酸共轭体,可以抑制固醇调节元件结合蛋白 (SREBP) 的活性,调节胆固醇代谢的蛋白质如 PCSK9,HMG-CoA reductase,ATP citrate lyase 和 NPC1L1 等的活性。
  • HY-13528
    Clinofibrate Inhibitor >98.0%
    Clinofibrate (S-8527)是一种降血脂药和一种HMG-CoA还原酶抑制剂。
  • HY-100793
    SR12813 Inhibitor 99.04%
    SR12813 是有效的3-羟基-3-甲基-戊二酰辅酶A还原酶 (HMG-CoA reductase) 抑制剂,IC50 值为 0.85 μM。
  • HY-17504S
    Rosuvastatin D6 Calcium Inhibitor 98.54%
    Rosuvastatin D6钙盐是Rosuvastatin的氘代化合物标准品。
  • HY-14664
    Fluvastatin Inhibitor
    Fluvastatin (XU 62320) 能抑制HMG-CoA还原酶活性,IC50为 8 nM。
  • HY-B0144A
    Pitavastatin Inhibitor
    Pitavastatin (NK-104)是HMG-CoA还原酶抑制剂,能抑制从醋酸到胆固醇的合成,IC50为5.8 nM。
  • HY-B0165
    Pravastatin Inhibitor
    Pravastatin (CS-514) 是HMG-CoA还原酶抑制剂,对甾醇合成的 IC50为 5.6 μM。
  • HY-B0589
    Atorvastatin Inhibitor
    Atorvastatin是HMG-CoA还原酶抑制剂,能抑制胆固醇的产生。
  • HY-B0144AS
    Pitavastatin D4 Inhibitor
    Pitavastatin D4是Pitavastatin氘代化合物标准品。
  • HY-17504BS
    Rosuvastatin D3 Sodium Inhibitor
    Rosuvastatin D3钠盐是Rosuvastatin氘代化合物标准品。
  • HY-14664AS
    Fluvastatin D6 sodium Inhibitor
    Fluvastatin (XU 62320) D6钠盐是Fluvastatin钠盐(HY-14664A)的氘代标记化合物。
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