1. GPCR/G Protein
    Immunology/Inflammation
  2. Histamine Receptor

Histamine Receptor

Histamine Receptors are a class of G protein-coupled receptors with histamine as their endogenous ligand. There are four known histamine receptors: H1 receptor, H2 receptor, H3 receptor, H4 receptor. The H1 receptor is a histamine receptor belonging to the family of Rhodopsin-like G-protein-coupled receptors. This receptor, which is activated by the biogenic amine histamine, is expressed throughout the body, to be specific, in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous system. H2 receptors are positively coupled to adenylate cyclase via Gs. It is a potent stimulant of cAMP production, which leads to activation of Protein Kinase A. Histamine H3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where they act asautoreceptors in presynaptic histaminergic neurons, and also control histamine turnover by feedback inhibition of histamine synthesis and release. The Histamine H4 receptor has been shown to be involved in mediating eosinophil shape change and mast cell chemotaxis.

Histamine Receptor 相关产品 (113):

Cat. No. Product Name Effect Purity
  • HY-17043
    Loratadine Agonist 99.95%
    Loratadine(SCH-29851)是H1受体反向激动剂,IC50>32 μM。
  • HY-12199B
    Pitolisant hydrochloride Antagonist 99.22%
    Pitolisant盐酸盐(BF2.649;Ciproxidine)是新型的人重组H3受体选择性反向激动剂,Ki为0.16 nM。
  • HY-14289
    Cimetidine Antagonist >98.0%
    Cimetidine是H2受体拮抗剂。
  • HY-N0054
    Osthole Inhibitor 99.81%
    Osthole 是一种天然抗组胺药替代试剂。Osthole 可有效抑制组胺 H1 受体 (histamine H1 receptor) 活性。
  • HY-B0298A
    Clemastine fumarate Antagonist 99.82%
    Clemastine延胡索酸盐是组胺H1受体拮抗剂,IC50为3 nM。
  • HY-101189
    JNJ-39758979 Antagonist 98.01%
    JNJ-39758979 是一个有选择性且具有高亲和性的组胺 H4 受体拮抗剂, 其 Ki 值为 12.5 nM。
  • HY-100191
    BMY-25271 Antagonist
    BMY-25271 是一个组胺 H2 受体 (histamine H2 receptor) 拮抗剂。
  • HY-100280
    Pirolate Antagonist
    Pirolate 是一种组胺 H1 受体。
  • HY-13508
    JNJ-7777120 Antagonist >98.0%
    JNJ-7777120是一种选择性的组胺H4受体拮抗剂, Ki值为4 ±1 nM,比作用于其他组胺受体选择性高1000多倍。
  • HY-30234A
    Clemizole hydrochloride Antagonist 99.70%
    Clemizole hydrochloride 是一种 H1 组胺受体 (H1 histamine receptor) 拮抗剂,抑制 HCV 复制。
  • HY-A0077
    Perphenazine Inhibitor 99.93%
    Perphenazine 是一种典型的抗精神病药物, 抑制5-HT2A 受体(5-HT2A), Alpha-1A肾上腺素受体(α1A), 多巴胺受体D2/D3, D2L, 和组胺 H1 受体 (H1), Ki值分别为5.6, 10, 0.765/0.13, 3.4, 和 8 nM.
  • HY-15538
    Ebrotidine Antagonist
    Ebrotidine(FI 3542)是竞争性H2受体拮抗剂,Ki为127.5nM,具有抗分泌活性,可用于胃保护。
  • HY-B1204
    Histamine Activator
    Histamine是一种参与局部免疫反应的有机含氮化合物, 调节肠道生理功能, 且作为神经递质。
  • HY-B0539
    Desloratadine Antagonist 99.75%
    Desloratadine(Sch34117)是人H1受体拮抗剂。
  • HY-B0377
    Famotidine Antagonist 98.17%
    Famotidine是组胺H2受体拮抗剂,可抑制胃液分泌。
  • HY-15289
    Ciproxifan maleate Antagonist 99.56%
    Ciproxifan(FUB-359)马来酸盐是高活性的H3受体拮抗剂,IC50为9.2 nM,对其它亚型受体的亲和力较低。
  • HY-17042A
    Cetirizine dihydrochloride Inhibitor 99.17%
    Cetirizine二盐酸盐是第二代抗组胺剂,是hydroxyzine的主要代谢产物,是外消旋的选择性H1受体反向激动剂。
  • HY-B0462
    Azelastine hydrochloride Antagonist 99.95%
    Azelastine盐酸盐是第二代H1受体拮抗剂。
  • HY-14537
    Latrepirdine dihydrochloride Antagonist 99.75%
    Latrepirdine dihydrochloride 是一种神经活性化合物,对组胺受体 (histaminergic receptor),α-肾上腺素能受体 (α-adrenergic receptor) 和 5-羟色胺受体 (serotonergic receptor) 具有拮抗活性。Latrepirdine 刺激淀粉样前体蛋白 (APP) 分解代谢和 β-淀粉样蛋白 (amyloid-β, ) 分泌。
  • HY-12195
    ABT-239 Antagonist 98.94%
    ABT-239 是一种新颖的,高效的,非咪唑类的 H3R 拮抗剂,也是 TRPV1 的拮抗剂。
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