1. Cell Cycle/DNA Damage
  2. LIM Kinase (LIMK)

LIM Kinase (LIMK)

LIM kinases (LIMKs) are important cell cytoskeleton regulators that play a prominent role in cancer manifestation and neuronal diseases. The LIMK family consists of two homologues, LIMK1 and LIMK2, which differ from one another in expression profile, intercellular localization, and function. The main substrate of LIMK is cofilin, a member of the actin-depolymerizing factor (ADF) protein family. When phosphorylated by LIMK, cofilin is inactive. LIMKs play a contributory role in several neurodevelopmental disorders and in cancer growth and metastasis.

LIM domain kinases (LIMK1 and 2) are substrate for Cdc42/Rac-PAK, and modulate actin dynamics by phosphorylating cofilin at serine-3. This modification inactivates cofilin’s actin severing and depolymerizing activity. LIMKs also translocate into the nucleus and regulate cell cycle progression. LIMKs are potential therapeutic targets for NF2 and other merlin-deficient tumors.

LIM Kinase (LIMK) 相关产品 (3):

Cat. No. Product Name Effect Purity
  • HY-18305
    BMS-5 Inhibitor 99.89%
    BMS-5是LIMK的抑制剂,LIMK1和LIMK2的IC50分别是7和8 nM, 可以抑制MDA-MB-231乳腺癌细胞中丝切蛋白的磷酸化,
  • HY-18304
    BMS-3 Inhibitor
    BMS-3是LIMK1有效的抑制剂,LIMK1活性对于细胞迁移和细胞周期进程是必须的。
  • HY-19352
    T56-LIMKi Inhibitor 98.02%
    T56-LIMKi是选择性的LIMK2抑制剂。抑制Panc-1细胞生长的IC50值为35.2 μM。