1. Membrane Transporter/Ion Channel
  2. Monoamine Transporter

Monoamine Transporter

Monoamine transporters (MATs) are protein structures that function as integral plasma-membrane transporters to regulate concentrations of extracellular monoamine neurotransmitters. Three major classes of MATs (SERT, DAT, NET) are responsible for the reuptake of their associated amine neurotransmitters (serotonin, dopamine, norepinephrine). MATs are located just outside the synaptic cleft (peri-synaptically), transporting monoamine transmitter overflow from the synaptic cleft back to the cytoplasm of the pre-synaptic neuron. MAT regulation generally occurs throughphosphorylation and posttranslational modification. Due to their significance in neuronal signaling, MATs are commonly associated with drugs used to treat mental disorders as well as recreational drugs. Compounds targeting MATs range from medications such as the wide variety of tricyclic antidepressants, selective serotonin reuptake inhibitors to stimulantmedications and amphetamine.

Monoamine Transporter 相关产品 (11):

Cat. No. Product Name Effect Purity
  • HY-B1618
    Corticosterone Inhibitor 99.29%
    Corticosterone作用于单胺转运体, 有效抑制有机阳离子转运体。
  • HY-N0480
    Reserpine Inhibitor 99.83%
    Reserpine (Serpalan)是一种吲哚生物碱,能不可逆地阻断囊泡单胺转运体(VMAT),有抗高血压的效果。
  • HY-B0590
    Tetrabenazine Inhibitor 99.10%
    Tetrabenazine是VMAT抑制剂,可作用于多动性运动障碍。
  • HY-15793
    NBI-98782 Inhibitor
    NBI-98782(alpha-dihydrotetrabenazine)是囊泡单胺转运体(VMAT2)抑制剂,Ki为0.97nM。
  • HY-B0590B
    Tetrabenazine (+)- Inhibitor
    Tetrabenazine ((+)-)是一个可逆转的VMAT-2的抑制剂。
  • HY-B0590A
    Tetrabenazine Racemate Inhibitor >98.0%
    Tetrabenazine (Racemate)是一个有选择性和可逆转的VMAT-2抑制剂。
  • HY-101416
    Vanilpyruvic acid >98.0%
    Vanilpyruvic acid是儿茶酚胺代谢物和香草酸的前体。
  • HY-N0480A
    Reserpine hydrochloride Inhibitor
    Reserpine盐酸盐(Serpalan)是一种吲哚生物碱,能不可逆的阻断囊泡单胺转运体(VMAT)。
  • HY-B0590S
    Tetrabenazine D6 Inhibitor
    Tetrabenazine D6是Tetrabenazine的氘代化合物标准品。
  • HY-17590
    Radafaxine hydrochloride Inhibitor
    Radafaxine盐酸盐是bupropion的代谢活化物,DAT/NET转运体抑制剂,能抑制去甲肾上腺素的再吸收。
  • HY-15793A
    NBI-98854 Inhibitor
    NBI-98854是高选择性囊泡单胺转运体(VMAT2)抑制剂。