1. GPCR/G Protein
  2. Neuropeptide Y Receptor

Neuropeptide Y Receptor

Neuropeptide Y receptors are a class of G-protein coupled receptors which are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are involved in the control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.

Neuropeptide Y (NPY) is a potent orexigenic neuropeptide, and antagonism of NPY Y1 and NPY Y5 receptors (NPYxR) is considered a potentially important anti-obesity drug target.

Neuropeptide Y (NPY) is widely distributed in the human body and contributes to a vast number of physiological processes. A number of other uses for modulators of NPY receptors have been implied in a range of diseases.

Neuropeptide Y Receptor 相关产品 (18):

Cat. No. Product Name Effect Purity
  • HY-14423
    Velneperit Antagonist 99.65%
    Velneperit (S-2367) 是一种新型神经肽Y (NPY) Y5受体拮抗剂。
  • HY-100717
    HT-2157 Antagonist >98.0%
    HT-2157(SNAP 37889) 是一种选择性的高亲和力甘丙肽-3 受体 (Gal3) 竞争性拮抗剂。
  • HY-15411
    MK-0557 Antagonist 98.28%
    MK-0557是具有高度选择性,口服活性的神经肽Y5受体拮抗剂,Ki值为1.6 nM。
  • HY-14450
    JNJ-31020028 Antagonist
    JNJ-31020028是神经肽Y2受体选择性可脑渗透抑制剂,对人Y2和鼠源Y2受体pIC50值分别为8.07和8.22,对人源Y1、Y4和Y5受体抑制作用要弱100倍以上。
  • HY-107382
    RF9 Antagonist 98.24%
    RF9 是一种有效且有选择性的神经肽FF受体 (Neuropeptide FF receptor) 拮抗剂 ,对于 hNPFF1RhNPFF2RKi 值分别为 58±5 和 75±9 nM。
  • HY-P1601
    Neuropeptide Y(29-64)
    Neuropeptide Y(29-64) 是由 36 个氨基酸组成的多肽,为神经肽 Y 的一个片段。
  • HY-P1578
    Galanin (1-16), mouse, porcine, rat Agonist
    Galanin (1-16), mouse, porcine, rat 是一种甘丙肽 (galanin) 受体激动剂,Kd 值为 3 nM。
  • HY-P1532
    Pancreatic Polypeptide, rat Agonist
    Pancreatic Polypeptide, rat 是神经肽 (NPY) 受体激动剂,对 NPYR4 有很高的亲和性。
  • HY-P1025
    M40 Antagonist 98.25%
    M40 是一个有效的,非竞争性的 galanin receptor 拮抗剂。
  • HY-P0262
    Galantide Antagonist
    Galantide是一种可逆的非特异性甘丙肽受体拮抗剂。
  • HY-P1514
    Peptide YY (PYY), human
    Peptide YY (PYY) 是一种肠道激素,可调节食欲和抑制胰腺分泌。Peptide YY (PYY) 可以通过神经肽 Y 受体 (Neuropeptide Y receptors) 介导其作用。
  • HY-P0199
    Pancreatic Polypeptide, human Agonist
    Pancreatic Polypeptide, human 是一种 C-末端酰胺化的含 36 个氨基酸的多肽,用作神经肽 Y (NPY) Y4/Y5 受体激动剂。
  • HY-101986
    BIIE-0246 Antagonist
    BIIE-0246 是一种有效的、非肽神经肽 Y (NPY) Y2 受体的高度选择性拮抗剂,其IC50 值为 15±3 nM。
  • HY-P1480
    Neuropeptide Y (13-36), amide, human Agonist
    Neuropeptide Y (13-36), amide, human是神经肽Y受体 (neuropeptide Y receptor) 激动剂。
  • HY-P1537
    Pancreatic Polypeptide, bovine Agonist
    Pancreatic Polypeptide, bovine 是由 36 个氨基酸组成的直链多肽,由胰腺中产生,能够抑制由分泌素和胆囊素诱导的胰腺分泌。Pancreatic Polypeptide, bovine 是神经肽 (NPY) 受体激动剂,对 NPYR4 有很高的亲和性。
  • HY-P1127
    Galanin (1-30), human Agonist
    Galanin (1-30), human 是由 30 个氨基酸构成的神经肽,为甘丙肽 GalR1GalR2 受体的有效激动剂,Ki 值均为 1 nM。
  • HY-U00335
    FR252384 Antagonist
    FR252384 是一种有效的 neuropeptide Y-Y5 receptor 拮抗剂,IC50 值为 2.3 nM。
  • HY-P0198
    Neuropeptide Y (29-64), amide, human
    Neuropeptide Y (29-64), amide, human 是一种具有生物活性的含有 36 个氨基酸的多肽。
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