1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor

Opioid Receptor

Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.

Opioid Receptor 相关产品 (54):

Cat. No. Product Name Effect Purity
  • HY-17417
    Naloxone hydrochloride Antagonist 99.86%
    Naloxone hydrochloride 是一种有效的 opioid receptor 拮抗剂,能够对抗阿片类药物过量造成的影响。
  • HY-75766
    Methylnaltrexone Bromide Antagonist 98.59%
    Methylnaltrexone Bromide 是一种有效的阿片受体 (opioid receptor) 拮抗剂,能够降低肠道内由阿片类物质导致的便秘症状。
  • HY-12745A
    Nalfurafine hydrochloride Agonist 98.27%
    Nalfurafine hydrochloride是一种κ-opioid激动剂,是日本批准的抗瘙痒药物。
  • HY-16655A
    TRV130 hydrochloride Agonist
    TRV130 hydrochloride 是新颖的 MOR 激动剂,能够优先激活 G-protein 信号通路,而对 β-arrestin 的作用稍弱。
  • HY-10487
    JDTic dihydrochloride Antagonist 98.18%
    JDTic dihydrochloride 是一种有效的 kappa-opioid receptors (KOR) 的拮抗剂,常用于神经系统疾病的研究。
  • HY-76711
    Naltrexone Antagonist 99.94%
    Naltrexone是μ, κ, δ和σ-阿片受体拮抗剂。
  • HY-70042A
    Tapentadol hydrochloride Agonist 98.53%
    Tapentadol hydrochloride 是有效的μ-阿片受体 (μ-opioid receptor) 激动剂,也是去甲肾上腺素再摄取抑制剂 (norepinephrine reuptake inhibitor)。
  • HY-13274
    JTC-801 Antagonist 99.63%
    JTC-801 是一种具有选择性的 opioid receptor-like1 (ORL1) receptor 抑制剂,其 Ki 值为 8.2 nM。
  • HY-13044
    ADL-5859 Agonist 98.81%
    ADL5859是δ-阿片受体选择性激动剂,Ki为0.8 nM,对hERG有弱抑制性。
  • HY-P0073
    Tyr-Gly-Gly-Phe-Met-OH Activator 99.89%
    Tyr-Gly-Gly-Phe-Met-OH (Methionine enkephalin) 是一种生物活性肽, 对神经系统和免疫系统都有重要作用,用于生化研究和神经生物学研究。
  • HY-15536
    Cebranopadol Agonist 98.24%
    Cebranopadol 是NOPopioid receptor 激动剂,作用于人NOP,MOP,KOP 和δ-阿片肽(DOP)受体,Ki/EC50 分别为 0.9 nM/13 nM,0.7 nM/1.2 nM,2.6 nM/17 nM,18 nM/110 nM。
  • HY-13754A
    Sufentanil citrate Agonist
    Sufentanil(R30730)柠檬酸盐是mu-阿片受体激动剂,较其母体化合物fentanyl活性高5到10倍。
  • HY-101386
    PZM21 Agonist 98.54%
    PZM21是高效选择性的μ opioid receptor受体激动剂,EC50值为1.8 nM。
  • HY-12247
    Eluxadoline Modulator
    Eluxadoline 是一种 μ-κ- 阿片受体激动剂,是 δ- 阿片受体拮抗剂。
  • HY-A0118A
    Naloxegol oxalate Antagonist 99.73%
    Naloxegol 草酸盐是一种CYP3A4酶抑制剂, 是一个外周选择性阿片类拮抗剂, 用于治疗阿片样物质引起的便秘。
  • HY-B0418A
    Loperamide hydrochloride Agonist 99.39%
    Loperamide盐酸盐是阿片类受体激动剂,是长效止泻剂。
  • HY-76710
    Naltrexone Hydrochloride Antagonist 99.91%
    Naltrexone盐酸盐是阿片受体拮抗剂。
  • HY-13222
    BAN ORL 24 Antagonist
    BAN ORL 24是NOP受体拮抗剂,对NOP,κ-,μ-和δ-受体的IC50分别为0.27,2500,6700和> 10000 nM。
  • HY-N0164
    Matrine Agonist 99.80%
    Matrine(Sophocarpidine; α-Matrine)是来源于植物的生物碱,有抗肿瘤活性,是kappa阿片受体激动剂。
  • HY-13754
    Sufentanil
    Sufentanil(R30730)是mu-阿片受体激动剂,较其母体化合物fentanyl活性高5到10倍。