1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor

Opioid Receptor

Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.

Opioid Receptor 相关产品 (63):

Cat. No. Product Name Effect Purity
  • HY-12745A
    Nalfurafine hydrochloride Agonist 99.93%
    Nalfurafine hydrochloride是一种κ-opioid激动剂,是日本批准的抗瘙痒药物。
  • HY-75766
    Methylnaltrexone Bromide Antagonist 98.59%
    Methylnaltrexone Bromide 是一种有效的阿片受体 (opioid receptor) 拮抗剂,能够降低肠道内由阿片类物质导致的便秘症状。
  • HY-76710
    Naltrexone Hydrochloride Antagonist 99.99%
    Naltrexone盐酸盐是阿片受体拮抗剂。
  • HY-16655A
    TRV130 hydrochloride Agonist 99.67%
    TRV130 hydrochloride 是新颖的 MOR 激动剂,能够优先激活 G-protein 信号通路,而对 β-arrestin 的作用稍弱。
  • HY-101386
    PZM21 Agonist 98.54%
    PZM21是高效选择性的μ opioid receptor受体激动剂,EC50值为1.8 nM。
  • HY-105343
    DADLE Agonist 98.95%
    DADLE ([D-Ala2, D-Leu5]-Enkephalin) 是水溶性的多肽类阿片受体 (Opioid Receptor) 激动剂。
  • HY-111454
    SR17018 Agonist >98.0%
    SR17018 是一种 mu 型阿片受体 (mu-opioid-receptor) 激动剂,能够与 GTPγS 结合,EC50 值为 97 nM。
  • HY-100903
    Norbinaltorphimine dihydrochloride Antagonist >98.0%
    Norbinaltorphimine dihydrochloride是一种有效的和选择性的κ阿片受体 (κ opioid receptor) 拮抗剂。
  • HY-13044
    ADL-5859 Agonist 99.65%
    ADL5859是δ-阿片受体选择性激动剂,Ki为0.8 nM,对hERG有弱抑制性。
  • HY-B0418A
    Loperamide hydrochloride Agonist 99.69%
    Loperamide盐酸盐是阿片类受体激动剂,是长效止泻剂。
  • HY-G0021
    N-Desmethylclozapine Agonist 98.66%
    N-Desmethylclozapine 是登革病毒抑制剂,同时为 δ-opioid 受体的激动剂。
  • HY-10487
    JDTic dihydrochloride Antagonist 98.18%
    JDTic dihydrochloride 是一种有效的 kappa-opioid receptors (KOR) 的拮抗剂,常用于神经系统疾病的研究。
  • HY-P0073
    Tyr-Gly-Gly-Phe-Met-OH Activator 99.89%
    Tyr-Gly-Gly-Phe-Met-OH (Methionine enkephalin) 是一种生物活性肽, 对神经系统和免疫系统都有重要作用,用于生化研究和神经生物学研究。
  • HY-13274
    JTC-801 Antagonist 99.20%
    JTC-801 是一种具有选择性的 opioid receptor-like1 (ORL1) receptor 抑制剂,其 Ki 值为 8.2 nM。
  • HY-101718
    LY-2456302 Antagonist 99.24%
    LY-2456302是一种有效地可渗透中枢神经的kappa opioid受体拮抗剂,Ki值为0.807 nM。
  • HY-N0164
    Matrine Agonist >98.0%
    Matrine(Sophocarpidine; α-Matrine)是来源于植物的生物碱,有抗肿瘤活性,是kappa阿片受体激动剂。
  • HY-15536
    Cebranopadol Agonist 98.24%
    Cebranopadol 是NOPopioid receptor 激动剂,作用于人NOP,MOP,KOP 和δ-阿片肽(DOP)受体,Ki/EC50 分别为 0.9 nM/13 nM,0.7 nM/1.2 nM,2.6 nM/17 nM,18 nM/110 nM。
  • HY-101177
    Naltrindole hydrochloride Antagonist 99.68%
    Naltrindole hydrochloride是高效,选择性的非多肽类 δ opioid 受体拮抗剂,Ki值为0.02 nM。
  • HY-15122A
    Sinomenine hydrochloride Activator >98.0%
    Sinomenine hydrochloride 是 NF-κB 活化的阻断剂,也是 μ 阿片受体 (μ-opioid receptor) 的激活剂。
  • HY-P1013
    Deltorphin 2 Agonist 98.20%
    Deltorphin 2 是一种选择性的 δ 阿片受体肽激动剂。
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