1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. P2X Receptor

P2X Receptor

P2X receptors are a family of cation-permeable ligand gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). They belong to a larger family of receptors known as the purinergic receptors. P2X receptors are present in a diverse array of organisms including humans, mouse, rat, rabbit, chicken, zebrafish, bullfrog, fluke, and amoeba. seven separate genes coding for P2X subunits have been identified, and named to as P2X1 through P2X7. The pharmacology of a given P2X receptor is largely determined by its subunit makeup. Different subunits exhibit different sensitivities to purinergic agonists and antagonists. Of continuing interest is the fact that some P2X receptors (P2X2, P2X4, human P2X5, and P2X7) exhibit multiple open states in response to ATP, characterized by a time-dependent increase in the permeabilities of large organic ions and nucleotide binding dyes.

P2X Receptor 相关产品 (18):

Cat. No. Product Name Effect Purity
  • HY-B0345A
    ATP disodium salt Agonist >98.0%
    ATP disodium salt 是用于代谢反应中底物活化的磷酸基团供体和大量激酶的辅酶。
  • HY-13290
    KN-62 Antagonist 99.16%
    KN-62 是一种有效,选择性的钙调蛋白依赖性蛋白激酶 II (CaMK-II)抑制剂,IC50 为 0.9 μM, KN-62 也是非竞争性的 P2X7 受体拮抗剂,IC50 约为 15 nM。
  • HY-50697
    A-740003 Antagonist 98.91%
    A-740003 是一种有效的,选择性的,竞争性的 P2X7 receptor 拮抗剂,抑制大鼠和人的 P2X7 受体,IC50 值分别为 18 和 40 nM。
  • HY-15488
    A 438079 Antagonist 99.64%
    A 438079是P2X7受体拮抗剂,能抑制人重组P2X7细胞系的钙流,pIC50为6.9。
  • HY-19427A
    AZD9056 hydrochloride Inhibitor 98.10%
  • HY-101588
    Gefapixant Antagonist 99.62%
    Gefapixant 是一个口服的、P2X3 受体活性拮抗剂,其对人同源重组 hP2X3 和 hP2X2/3 的 IC50 值分别是 ~30 nM 和 100-250 nM。
  • HY-100483
    A-804598 Antagonist 98.83%
    A-804598 是一个 CNS 渗透,竞争性和选择性的 P2X7 受体拮抗剂,作用于小鼠,大鼠和人的 P2X7 受体,IC50s 分别是 9 nM, 10 nM 和 11 nM。
  • HY-15568
    A-317491 Antagonist 99.18%
  • HY-14483
    AF-353 Antagonist 98.95%
    AF-353 (Ro-4) 是一种有效选择性、口服可利用的 P2X3/P2X2/3 受体拮抗剂, 抑制人和大鼠 P2X3 的 pIC50 值为 8.0,抑制人 P2X2/3 的 pIC50 值为 7.3。
  • HY-101910
    PSB-12062 Antagonist 98.45%
    PSB-12062是有效,选择性的 P2X4 拮抗剂,对人类 P2X4 的 IC50 值为1.38 μM。
  • HY-13954
    A 839977 Antagonist 98.74%
    A 839977是一种选择性 P2X7 受体拮抗剂, 可阻断人和大小鼠 P2X7 受体的 BzATP 诱发的钙内流 (IC50s=20 nM, 42 nM / 150 nM); 在体实验中, 通过阻断 IL-1β 释放产生抗痛觉过敏反应, 减弱模型动物的炎症反应与神经性疼痛.
  • HY-15488A
    A 438079 (hydrochloride) Antagonist 99.88%
    A 438079 hydrochloride 是一种有效的,选择性的 P2X7 受体拮抗剂,pIC50 值为 6.9。
  • HY-15568A
    A-317491 sodium salt hydrate Antagonist 99.65%
  • HY-N0383
    Lappaconitine Inhibitor
    高乌甲素 (Lappaconitine) 是从高乌头中分离到的一种天然产物,具有镇痛作用。
  • HY-15469
    GW791343 dihydrochloride Inhibitor
  • HY-15470
    GW791343 trihydrochloride Inhibitor
  • HY-117508
    JNJ-54175446 Antagonist
    JNJ-54175446 是一种有效、选择性、可透过血脑屏障的 P2X7 受体拮抗剂,对人和大鼠的 P2X7 受体的 pIC50 值分别为 8.46 和 8.81。
  • HY-15487
    CE-224535 Antagonist
    CE-224535 是一个有选择性的 P2X7 受体拮抗剂。
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