1. Membrane Transporter/Ion Channel
  2. P2X Receptor

P2X Receptor

P2X receptors are a family of cation-permeable ligand gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). They belong to a larger family of receptors known as the purinergic receptors. P2X receptors are present in a diverse array of organisms including humans, mouse, rat, rabbit, chicken, zebrafish, bullfrog, fluke, and amoeba. seven separate genes coding for P2X subunits have been identified, and named to as P2X1 through P2X7. The pharmacology of a given P2X receptor is largely determined by its subunit makeup. Different subunits exhibit different sensitivities to purinergic agonists and antagonists. Of continuing interest is the fact that some P2X receptors (P2X2, P2X4, human P2X5, and P2X7) exhibit multiple open states in response to ATP, characterized by a time-dependent increase in the permeabilities of large organic ions and nucleotide binding dyes.

P2X Receptor 相关产品 (15):

Cat. No. Product Name Effect Purity
  • HY-B0345A
    ATP disodium salt Agonist 98.47%
  • HY-13290
    KN-62 Antagonist 99.16%
    KN-62 是一种有效的选择性的钙调蛋白依赖性蛋白激酶 II (CaMK-II)抑制剂,IC50 为 0.9 μM,在HEK293 细胞中,KN-62 也非竞争性拮抗P2X7 受体,IC50 约为 15 nM。
  • HY-50697
    A-740003 Antagonist
    A-740003 是一种有效的,选择性的,竞争性的 P2X7 receptor 拮抗剂,抑制大鼠和人的 P2X7 受体,IC50 值分别为 18 和 40 nM。
  • HY-14483
    AF-353 Antagonist 98.95%
    AF-353是一种新的, 有效的P2X3/ P2X2/3受体拮抗剂, 抑制人和大鼠P2X3 (pIC50=8.0)。
  • HY-15568
    A-317491 Antagonist 99.56%
  • HY-15488A
    A 438079 (hydrochloride) Antagonist 99.74%
    A 438079 hydrochloride 是一种有效的,选择性的 P2X7 受体拮抗剂,pIC50 值为 6.9。
  • HY-15568A
    A-317491 sodium salt hydrate Antagonist 99.76%
  • HY-15488
    A 438079 Antagonist 99.73%
    A 438079是P2X7受体拮抗剂,能抑制人重组P2X7细胞系的钙流,pIC50为6.9。
  • HY-19427A
    AZD9056 hydrochloride Inhibitor 98.10%
  • HY-13954
    A 839977 Antagonist 98.05%
    A-839977是选择性P2X7受体拮抗剂,能阻断BzATP激发的钙流,对人、大小鼠的P2X7受体的IC50分别为20,42和150 nM。
  • HY-101910
    PSB-12062 Antagonist 98.45%
    PSB-12062是有效,选择性的 P2X4 拮抗剂,对人类 P2X4 的 IC50 值为1.38 μM。
  • HY-100483
    A-804598 Antagonist 99.01%
    A-804598是一个强的,竞争性,和选择性的P2X7受体拮抗剂,在大鼠,小鼠和体内的IC50分别是10 nM, 9 nM 和11 nM。
  • HY-15469
    GW791343 dihydrochloride Inhibitor
  • HY-N0383
    Lappaconitine Inhibitor
    高乌甲素 (Lappaconitine) 是从高乌头中分离到的一种天然产物,具有镇痛作用。
  • HY-15470
    GW791343 trihydrochloride Inhibitor