1. Protein Tyrosine Kinase/RTK
  2. Pyk2

Pyk2

Proline-rich tyrosine kinase 2 (Pyk2) is a cytoplasmic, non-receptor tyrosine kinase implicated in multiple signaling pathways. It is a negative regulator of osteogenesis and considered a viable drug target for osteoporosis treatment.

Pyk2 and focal adhesion kinase (FAK) comprise the focal adhesion kinase subfamily of non-receptor tyrosine kinases. PYK2 and FAK are large multidomain proteins containing an N-terminal FERM domain, a central catalytic domain, and a C-terminal segment containing dual proline rich (PR) subdomains and a focal adhesion targeting (FAT) region.

Pyk2, a non-receptor tyrosine kinase of the FAK family, is up-regulated in more than 60% of the tumors of hepatocellular carcinoma (HCC) patients.

Pyk2 相关产品 (4):

Cat. No. Product Name Effect Purity
  • HY-10459
    PF-562271 Inhibitor 99.36%
    PF-562271 是有效的ATP竞争性的可逆 FAKPyk2 激酶抑制剂,IC50 分别为 1.5 和 13 nM。
  • HY-10460
    PF-431396 Inhibitor 99.15%
    PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively), PF-431396 has a Kd value of 445 nM for BRD4.
  • HY-13203
    NVP-TAE 226 Inhibitor 98.98%
    NVP-TAE 226 是一种双重酪氨酸激酶抑制剂,作用于 FAKIGF-IRIC50 分别为 5.5 nM 和 0.14 μM。
  • HY-10458
    PF-562271 besylate Inhibitor 98.31%
    PF-562271 besylate 是一种有效的,ATP 竞争性的,可逆的 FAKPyk2 kinase 抑制剂,IC50 值分别为 1.5 nM 和 13 nM,对其活性是对CDK酶以外的其他酶的 100 多倍。
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