1. Cell Cycle/DNA Damage
  2. SRPK

SRPK

SRPKs is a critical enzyme family that regulates splicing activity in the cell. The first serine-arginine (SR) protein kinase identified is SRPK1, which is isolated from mitotic cells, and it is described to phosphorylate SR proteins and to promote their release from nuclear speckles during the G2/M phase of the cell cycle. SRPK1 is the prototype of the SRPK family, which also includes the two homologous SRPK2 and SRPK3 proteins. SRPKs are characterized by a bipartite catalytic domain separated by a unique spacer sequence and are mainly localized in the cytoplasm of mammalian cells.

SRPKs can translocate into the nucleus of cells under several conditions, such as during the G2/M phase of the cell cycle, or after osmotic stress, or as a consequence of activation of the epidermal growth factor (EGF) signal transduction pathway.

SRPK 相关产品 (2):

Cat. No. Product Name Effect Purity
  • HY-13949
    SRPIN340 Inhibitor 99.96%
    SRPIN340 是一种 ATP 竞争性的 SRPK抑制剂,能够抑制 SRPK1 的活性,Ki 值为 0.89 μM。
  • HY-116856
    SRPKIN-1 Inhibitor
    SRPKIN-1是共价,不可逆的 SRPK1/2 抑制剂,IC50 分别为35.6 和 98 nM。有抗血管生成作用。
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