1. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel Apoptosis
  2. Endogenous Metabolite Cholinesterase (ChE) Potassium Channel Apoptosis
  3. Uridine 5'-monophosphate disodium salt

Uridine 5'-monophosphate disodium salt  (Synonyms: 尿苷-5'-单磷酸二钠盐; 5'-​Uridylic acid disodium salt)

目录号: HY-W013175 纯度: 99.90%
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Uridine 5'-monophosphate (5'-Uridylic acid) disodium salt 是一种具有口服活性的线粒体 ATP 依赖性钾通道 (potassium channel) 激活剂,具有心脏保护作用。Uridine 5'-monophosphate disodium salt 可促进 CDP-choline 的合成并诱导肠上皮细胞凋亡 (apoptosis),有利于肠道发育,减少腹泻。

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Uridine 5'-monophosphate disodium salt Chemical Structure

Uridine 5'-monophosphate disodium salt Chemical Structure

CAS No. : 3387-36-8

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10 mM * 1 mL in Water ¥110
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Other Forms of Uridine 5'-monophosphate disodium salt:

查看 Cholinesterase (ChE) 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Uridine 5'-monophosphate (5'-Uridylic acid) disodium salt is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate disodium salt can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea[1][2][3].

体外研究
(In Vitro)

Uridine 5'-monophosphate (10 mM; 6 h) disodium salt 促进猪肠上皮细胞 IPEC-J2 的晚期凋亡[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: IPEC-J2
Concentration: 10 mM
Incubation Time: 6 h
Result: Increased the late apoptosis rate.
体内研究
(In Vivo)

Uridine 5'-monophosphate (476 mg; 口服; 10 天) disodium salt 促进猪肠绒毛尖端上皮细胞凋亡和更新,利于肠道发育,降低腹泻率[1]
Uridine 5'-monophosphate (0.02-1 mmol/kg; 灌胃; 单剂量) disodium salt 可促进沙鼠脑内 CDP-胆碱的合成[2]
Uridine 5'-monophosphate (30 mg/kg; 静脉注射; 单剂量) disodium salt 在大鼠中具有保护心脏特性,预防缺血性损伤和部分节律障碍[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Piglets[1]
Dosage: 476 mg; daily; 10 days
Administration: Oral
Result: Improved daily weight gain in piglets, reduced diarrhea rates, lowered the expression of jejunal mucosal CAD and RRM2, and increased the apoptosis rate of intestinal epithelial cells.
Animal Model: Male gerbils (60-80g)[2]
Dosage: 0.02, 0.05, 0.1, 1 mmol/kg, single dose
Administration: i.g.
Result: Increased choline levels after 15 minutes, and after thirty minutes, plasma uridine and brain tissue uridine increased, with plasma and brain cytidine also rising significantly.
Animal Model: Male wistar rats (250-300 g)[3]
Dosage: 30 mg/kg, single dose
Administration: i.v.
Result: Reduced the index of myocardial ischemia changes and T-wave amplitude, decreased the frequency of ventricular premature beats, and shortened the duration of ventricular tachycardia and fibrillation.
分子量

368.14

同用名

尿苷-5'-单磷酸二钠盐; 5'-​Uridylic acid disodium salt

Formula

C9H11N2Na2O9P

CAS 号
性状

固体

颜色

White to off-white

中文名称

尿苷-5'-单磷酸二钠盐

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验: 

H2O 中的溶解度 : ≥ 50 mg/mL (135.82 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7164 mL 13.5818 mL 27.1636 mL
5 mM 0.5433 mL 2.7164 mL 5.4327 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验:

以下溶解方案,请直接配制工作液。建议现用现配,在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比; 如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂: PBS

    Solubility: 100 mg/mL (271.64 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.90%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.7164 mL 13.5818 mL 27.1636 mL 67.9089 mL
5 mM 0.5433 mL 2.7164 mL 5.4327 mL 13.5818 mL
10 mM 0.2716 mL 1.3582 mL 2.7164 mL 6.7909 mL
15 mM 0.1811 mL 0.9055 mL 1.8109 mL 4.5273 mL
20 mM 0.1358 mL 0.6791 mL 1.3582 mL 3.3954 mL
25 mM 0.1087 mL 0.5433 mL 1.0865 mL 2.7164 mL
30 mM 0.0905 mL 0.4527 mL 0.9055 mL 2.2636 mL
40 mM 0.0679 mL 0.3395 mL 0.6791 mL 1.6977 mL
50 mM 0.0543 mL 0.2716 mL 0.5433 mL 1.3582 mL
60 mM 0.0453 mL 0.2264 mL 0.4527 mL 1.1318 mL
80 mM 0.0340 mL 0.1698 mL 0.3395 mL 0.8489 mL
100 mM 0.0272 mL 0.1358 mL 0.2716 mL 0.6791 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Uridine 5'-monophosphate disodium salt
目录号:
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