2. Neuronal Signaling
  3. Amyloid-β
  4. Aducanumab (Mouse IGG2a)

Aducanumab (Mouse IGG2a) 

目录号: HY-P990109
技术支持

Aducanumab (Mouse IGG2a) 是一种选择性靶向聚集的淀粉样 β 蛋白 (Aβ) 的单克隆抗体。Aducanumab (Mouse IGG2a) 的可变区与 Aducanumab (HY-P9967) 的可变区一致，而恒定区则为小鼠 IGG2a 序列。Aducanumab (Mouse IGG2a) 对 Aβ 原纤维具有很强的选择性，对单体 Aβ1-40 和原纤维 Aβ1-42 的 EC50 分别为 >1 μM 和 0.2 nM。Aducanumab (Mouse IGG2a) 可用于阿尔茨海默病 (AD) 研究。

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Aducanumab (Mouse IGG2a) Chemical Structure

Aducanumab (Mouse IGG2a) Chemical Structure

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Other Forms of Aducanumab (Mouse IGG2a):

Aducanumab (Mouse IGG2a) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Aducanumab (Mouse IGG2a) is a monoclonal antibody that selectively targets aggregated amyloid-beta (Aβ). The variable region of Aducanumab (Mouse IGG2a) is consistent with that of Aducanumab (HY-P9967), while the constant region is of Mouse IGG2a sequence. Aducanumab (Mouse IGG2a) has strong selectivity for Aβ fibrils with EC50s of >1 μM and 0.2 nM for monomeric Aβ1-40 and fibrillar Aβ1-42, respectively. Aducanumab (Mouse IGG2a) can be used for Alzheimer's disease (AD) research[1].

体外研究
(In Vitro)

Aducanumab (Mouse IGG2a) (0.31-40 μM，2 分钟) 具有极弱的单价结合力，其 Fab 与表面捕获的单体 Aβ1-40-biotin 的 KD 约为 9 μM[1]。
Aducanumab (Mouse IGG2a) (5 μM) 与 Aβ 肽的亲和力非常弱，对 Aβ1-16 和 Aβ1-28 的 KD 分别为 1.8 和 5.9 μM[1]。
Aducanumab (Mouse IGG2a) 与单聚体和四聚体多抗原肽 (MAPs) 的亲和力较弱，对于二聚体和四聚体 Aβ1-15 MAP 的 EC50 分别为 > 1 μM 和 ~7 nM[1]。
Aducanumab (Mouse IGG2a) 可有效结合过剩游离单体中的固定化 Aβ，其 IC50为 >1 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Aducanumab (Mouse IGG2a) 相关抗体:
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Aducanumab (Mouse IGG2a) 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aducanumab (Mouse IGG2a)Amyloid-ββ-amyloid peptideAβAbetaMonoclonal AntibodyAducanumabAggregated amyloid-betaAlzheimer's diseaseADInhibitorinhibitorinhibit

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