2. Others GPCR/G Protein Neuronal Signaling
  3. Reference Standards mGluR
  4. AMN082 free base (Standard)

AMN082 free base (Standard) 

目录号: HY-103565AR 纯度: ≥98%
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AMN082 (free base) (Standard)是 AMN082 (free base) 的分析标准品。本产品用于研究及分析应用。AMN082 free base 是一种选择性，具有口服活性，可透过血脑屏障的 mGluR7 激动剂，通过跨膜区的变构位点直接激活受体信号。在表达 mGluR7 的转染哺乳动物细胞上，AMN082 free base 有效抑制 cAMP 积累并刺激 GTPγS 结合 (EC50, 64-290 nM)。AMN082 free base 对其他 mGluR 亚型和选择性离子型谷氨酸受体具有选择性。具有抗抑郁作用。

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AMN082 free base (Standard) Chemical Structure

AMN082 free base (Standard) Chemical Structure

CAS No. : 83027-13-8

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生物活性

AMN082 (free base) (Standard) is the analytical standard of AMN082 (free base). This product is intended for research and analytical applications. AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 free base shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects.

分子量

392.54

Formula

C28H28N2
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

AMN082 free base (Standard) 相关分类

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Keywords:

AMN082 free base (Standard)83027-13-8Reference StandardsmGluRMetabotropic glutamate receptorsallostericoralblood-brainbarrierlocomotorsensitizationstresshormoneInhibitorinhibitorinhibit

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