1. Signaling Pathways
  2. GPCR/G Protein
  3. mGluR


mGluR (metabotropic glutamate receptor) is a type of glutamate receptor that are active through an indirect metabotropic process. They are members of thegroup C family of G-protein-coupled receptors, or GPCRs. Like all glutamate receptors, mGluRs bind with glutamate, an amino acid that functions as an excitatoryneurotransmitter. The mGluRs perform a variety of functions in the central and peripheral nervous systems: mGluRs are involved in learning, memory, anxiety, and the perception of pain. mGluRs are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and the cerebral cortex, as well as other parts of the brain and in peripheral tissues. Eight different types of mGluRs, labeled mGluR1 to mGluR8, are divided into groups I, II, and III. Receptor types are grouped based on receptor structure and physiological activity.

mGluR Isoform Specific Products:

  • mGluR8

  • mGluR6

  • mGluR7

  • mGluR5

  • mGluR4

  • mGluR2

  • mGluR3

mGluR 相关产品 (58):

Cat. No. Product Name Effect Purity
  • HY-N0390
    L-Glutamine Agonist >98.0%
  • HY-15257
    Mavoglurant Antagonist 99.99%
    Mavoglurant是一种结构新颖的非竞争性mGlu5受体拮抗剂,IC50为30 nM。
  • HY-101845
    FITM Inhibitor 98.82%
    FITM是mGlu1受体的负变构调节剂,Ki值为2.5 nM。
  • HY-18941
    Eglumegad Agonist >98.0%
    Eglumegad (LY354740) 是一种有效,选择性的 group II (mGlu2/3) receptor 激动剂,对人mGlu2和mGlu3受体的 IC50 分别为5和24 nM。
  • HY-18654
    ADX88178 Agonist 98.59%
    ADX88178 是一种有效的代谢型谷氨酸受体4 (mGluR4) 正变构调节剂,作用于人mGluR4,EC50为 4 nM。
  • HY-108703A
    Foliglurax monohydrochloride Agonist 98.93%
    Foliglurax monohydrochloride (PXT002331 monohydrochloride) 是一种可渗透脑的,有效的选择性 mGluR4 正变构调节剂 (PAM),EC50 为 79 nM。抗帕金森病。
  • HY-119243
    LY2794193 Agonist
    LY2794193 是一种高效的选择性 mGlu3 受体激动剂 (hmGlu3 Ki=0.927 nM,EC50=0.47 nM; hmGlu2 Ki=412 nM,EC50=47.5 nM)。
  • HY-112814
    VU6001376 是一种有效、选择性的变性谷氨酸受体 4 正变构调节剂 (mGlu4 PAM), 其 EC50 值为 50.1 nM。
  • HY-70059
    LY341495 Antagonist 99.11%
    LY341495 是一种代谢型谷氨酸受体 (mGluR) 拮抗剂,抑制 mGluR-2,mGluR-3,mGluR-8 的活性,IC50 值分别为 2.9 nM,10 nM,170 nM。
  • HY-100406
    (S)-MCPG Antagonist 98.10%
    (S)-MCPG是(RS)-MCPG的同分异构体,无选择性的 group I/group II metabotropic谷氨酸受体拮抗剂。
  • HY-14609
    MPEP Hydrochloride Antagonist 99.57%
    MPEP盐酸盐是非竞争性mGlu5受体拮抗剂,IC50为36 nM。
  • HY-100407
    JNJ16259685 Antagonist 98.85%
    JNJ16259685 是一种选择性的 mGlu1 receptor 拮抗剂,能够浓度依赖性地抑制 mGlu1 的突触的活化,IC50 值为 19 nM。
  • HY-15445
    CTEP Antagonist
    CTEP (RO 4956371) 是一种新颖的,长效的,可口服的 mGlu5 受体别构拮抗剂,IC50 值为 2.2 nM,对其选择性是对其他 mGlu 受体的 1000 多倍。
  • HY-B0122
    Topiramate Antagonist >98.0%
  • HY-100371
    (RS)-MCPG >98.0%
    (RS)-MCPG是一个非选择性的group I/group II代谢型谷氨酸受体的拮抗剂。
  • HY-15446
    Basimglurant Inhibitor 99.56%
    Basimglurant (RG7090) 是高效,选择性有口服活性的mGlu5负变构调节剂,Kd值为1.1 nM。
  • HY-15748
    JNJ-40411813 Agonist 99.69%
  • HY-13206
    MTEP hydrochloride Antagonist 99.73%
    MTEP hydrochloride 是非竞争性的mGlu5拮抗剂,IC50和Ki分别为5 nM和16 nM。
  • HY-50906
    LY404039 Inhibitor >98.0%
    LY404039是mGluR1和mGluR2的抑制剂,Ki分别为149 nM和92 nM,还能抑制多巴胺受体。
  • HY-100366
    Lu AF21934 Modulator 98.76%
    Lu AF21934是选择性和脑渗透性的mGlu4受体正变构调节剂。
Isoform Specific Products

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Please try each isoform separately.