2. GPCR/G Protein
  3. GHSR
  4. Anamorelin Fumarate

Anamorelin Fumarate  (Synonyms: 富马酸阿拉莫林; RC-1291 Fumarate; ONO-7643 Fumarate)

目录号: HY-14734B
产品使用指南 技术支持

Anamorelin (RC-1291) Fumarate 是一种口服有效的 Ghrelin 受体激动剂，EC50 为 0.74 nM。Anamorelin Fumarate 可促进食欲、增加体重、并刺激生长激素和胰岛素样生长因子-1 分泌。Anamorelin Fumarate 能够用于厌食和癌症恶病质的研究。

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Anamorelin Fumarate Chemical Structure

Anamorelin Fumarate Chemical Structure

CAS No. : 339539-92-3

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Anamorelin Fumarate 的其他形式现货产品:

Other Forms of Anamorelin Fumarate:

Anamorelin Fumarate 相关抗体

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GHSR1a

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anamorelin (RC-1291) Fumarate is an orally active Ghrelin receptor agonist with an EC50 of 0.74 nM. Anamorelin Fumarate can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin Fumarate can be used in the research of anorexia and cancer cachexia[1][2].

IC50 & Target

Ki: 0.7 nM (Ghrelin receptor)[1]
EC50: 0.74 nM (Ghrelin receptor)[1]
体外研究
(In Vitro)

Anamorelin (0.01 nM-10 μM; 15 min) Fumarate 在大鼠垂体细胞中剂量依赖性刺激生长激素释放，EC50 为 1.5 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anamorelin Fumarate 相关抗体:
体内研究
(In Vivo)

Anamorelin (3-30 mg/kg; 口服; 6 天) Fumarate 可剂量依赖性增加大鼠的食物摄入量和体重[1]。
Anamorelin (3.5 mg/kg; 口服; 1-7 天) Fumarate 在猪中可显著升高生长激素和胰岛素样生长因子-1 水平[1]。
Anamorelin (3-30 mg/kg; 口服; 28 天) Fumarate 在裸鼠肺癌异种移植模型中不促进肿瘤生长，但可增加裸鼠体重[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nude mice (nu/nu, Harlan) (18.4-26.6 g, 9-10 weeks old) treated A549 cells[2]
Dosage: 3, 10 and 30 mg/kg
Administration: Oral administration (p.o.); 28 days
Result: Did not promote tumor growth in the murine NSCLC xenograft model.
Significantly increased the percentage of mean body weight gain at the end of treatment at doses of 10 and 30 mg/kg compared with controls.
Significantly increased peak plasma levels of murine growth hormone (mGH), while peak murine insulin-like growth factor-1 (mIGF-1) levels were slightly elevated but not statistically significant.
Were well tolerated.
Clinical Trial
分子量

662.78

Formula

C35H46N6O7
CAS 号
中文名称

富马酸阿拉莫林
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anamorelin Fumarate 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anamorelin339539-92-3RC-1291ONO-7643富马酸阿拉莫林RC1291RC 1291ONO7643ONO 7643GHSRGrowth hormone secretagogue receptorGhrelin receptorrat pituitary cellsA549GHIGF-1Inhibitorinhibitorinhibit

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