2. Immunology/Inflammation
  3. CD3
  4. Anti-Mouse CD3 Antibody (17A2)

Anti-Mouse CD3 Antibody (17A2) 

目录号: HY-P99124 纯度: 98.56%
COA 技术支持

Anti-Mouse CD3 Antibody (17A2) 是一种源自宿主大鼠的抗小鼠 CD3 IgG2b 抗体抑制剂。Anti-Mouse CD3 Antibody (17A2) 可以增强 T 细胞增殖与活化，并刺激脾脏 T 细胞产生 IFN-γ 或 IL-17。Anti-Mouse CD3 Antibody (17A2) 可显著降低移植物抗宿主病 (GVHD) 模型小鼠的死亡率。

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Anti-Mouse CD3 Antibody (17A2) Chemical Structure

Anti-Mouse CD3 Antibody (17A2) Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥900
In-stock
5 mg ￥3600
In-stock
10 mg ￥6150
In-stock
50 mg   询价  
100 mg   询价  

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Anti-Mouse CD3 Antibody (17A2) 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD3 Antibody (17A2) is an anti-mouse CD3 IgG2b antibody inhibitor derived from the host Rat. Anti-Mouse CD3 Antibody (17A2) enhances T-cell proliferation and activation and stimulate IFN-γ or IL-17 production in splenic T cells. Anti-Mouse CD3 Antibody (17A2) significantly suppresses mortality in Graft-versus-host disease (GVHD) mice models[1][2].

同型

Rat IgG2b kappa
推荐同型对照抗体
体外研究
(In Vitro)

Anti-Mouse CD3 Antibody (17A2) (1-1000 ng/mL, 96 h) 可以增强 T 细胞增殖和活化，并刺激脾脏全 T 细胞中 IFN-γ 或 IL-17 的产生[1]。
Anti-Mouse CD3 Antibody (17A2) (1 μg/mL, 48 h) 显著提高脾脏 T 细胞中 Th1 和 IL - 17 基因的 mRNA 水平[1]。
Anti-Mouse CD3 Antibody (17A2) (48 h) 显著增强光感受器间类视黄醇结合蛋白 (IRBP) 刺激的眼细胞中 IFN-γ 的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD3 Antibody (17A2) 相关抗体:

RT-PCR[1]

Cell Line: Splenic T cells
Concentration: 1 μg/mL
Incubation Time: 48 h
Result: Increased the levels of IL-1α, IFN-γ, T-bet and IL-17 and decreased the levels of IL-10 and Foxp3.
体内研究
(In Vivo)

Anti-Mouse CD3 Antibody (17A2) (100 or 400 μg，静脉注射，单剂量) 可以小号小鼠体内的 T 细胞[2]。
Anti-Mouse CD3 Antibody (17A2) (200 or 400 μg, 静脉注射，照射后 20 小时以及移植前 4 小时) 可以显著降低移植物抗宿主病 (GVHD) 小鼠模型的死亡率[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice[2]
Dosage: 100 and 400 μg
Administration: Intravenously injection
Result: Significantly reduced T cells.
Animal Model: Graft-versus-host disease (GVHD) mice models[2]
Dosage: 200 and 400 μg
Administration: Intravenously injection, 20 h after irradiation and 4 h before spleen cells and bone marrow cells transplantation
Result: Suppressed GVHD mortality by about 50% on day 100 posttransplantation and 20% to 40% on day 200.
Prolonged antibody treatment by further injections of 200 μg on days 3,6, and 9 after transplantation led to long-term survivors with 90% to 97% chimerism on days 50 and 100.
Reduced CD4+ cells to about 50% and CD8+ cells to 10% after 50 days.
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 98.56%

COA (266 KB) SEC-HPLC (124 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse CD3 Antibody (17A2) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD3 Antibody (17A2)CD3Cluster of differentiation 3T cellsIFN γIL-17IRBPGVHDInhibitorinhibitorinhibit

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