2. Anti-infection
  3. Bacterial
  4. Antibacterial synergist 3

Antibacterial synergist 3 是双效生物膜 (biofilm) 抑制剂 (PAO1 的 IC50: 0.40 μM 和 PA14 的 IC50: 1.45 μM)。Antibacterial synergist 3 可通过抑制群体感应 (QS) 系统降低毒力产生并诱导铜绿假单胞菌 PAO1 发生铁缺乏。Antibacterial synergist 3 可增强小鼠伤口感染模型中 Tobramycin (HY-B0441) 和 Ciprofloxacin (HY-B0356) 的疗效。Antibacterial synergist 3 可用于铜绿假单胞菌感染的研究。

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Antibacterial synergist 3 Chemical Structure

Antibacterial synergist 3 Chemical Structure

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Antibacterial synergist 3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibacterial synergist 3 is a dual-acting inhibitor of biofilm (IC50 of PAO1: 0.40 μM and IC50 of PA14: 1.45 μM). Antibacterial synergist 3 reduces virulence production by inhibiting the quorum sensing (QS) system and induces iron deficiency in P. aeruginosa PAO1. Antibacterial synergist 3 enhances the efficacy of Tobramycin (HY-B0441) and Ciprofloxacin (HY-B0356) in a mouse wound infection model. Antibacterial synergist 3 can be used for the research of P. aeruginosa infections[1].

体外研究
(In Vitro)

Antibacterial synergist 3 (compound JH21) (0.15625-2.5 μM) 以浓度依赖性的方式降低铜绿假单胞菌 PAO1 的生物膜形成率[1]。
Antibacterial synergist 3 (0.3125-10 μM) 可降低铜绿假单胞菌毒力因子弹性蛋白酶 (43%) 和绿脓素 (42%) 的产量，并降低生物膜基质胞外多糖 (58%) 的产生[1]。
Antibacterial synergist 3 (0.3125-10 μM) 抑制了 PAO1-lasB-gfp 和 PAO1-pqsA-gfp 菌株的荧光，但对 PAO1-gfp 的荧光及其生长没有影响，表明它抑制 las 和 pqs 系统[1]。
Antibacterial synergist 3 (0.3125-10 μM) 可降低铜绿假单胞菌 PAO1 的铁含量 (57%)[1]。
Antibacterial synergist 3 (0.3125-10 μM) 以浓度依赖性的方式抑制了铜绿假单胞菌 PAO1 的群集运动 (84%) 和泳动能力 (64%)[1]。
Antibacterial synergist 3 (1.25-40 μM) 对小鼠和兔的红细胞未见明显溶血作用，表明其具有良好的生物安全性[1]。
Antibacterial synergist 3 (1.25-100 μM) 对 RAW264.7 细胞未表现出细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial synergist 3 相关抗体:
体内研究
(In Vivo)

Antibacterial synergist 3 (2.5 μM，局部给药，3 天) 与 Tobramycin (HY-B0441) (0.0025 mg/mL) 联合使用，可降低小鼠伤口感染模型中铜绿假单胞菌存活率 (0.97%)，并显著提高 Tobramycin (HY-B0441) 的抗菌效果 (200 倍)[1]。
Antibacterial synergist 3 (2.5 μM，局部给药，3 天) 与 Ciprofloxacin (HY-B0356) (0.001 mg/mL) 联合使用，可降低小鼠伤口感染模型中铜绿假单胞菌存活率 (0.45%)，并显著提高 Ciprofloxacin (HY-B0356) 的抗菌效果 (1000 倍)[1]。
Antibacterial synergist 3 (0-100 μM，0-120 小时) 在斑马鱼模型中未影响斑马鱼幼虫存活率(100%)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse wound infection model, female mice (4-week-old, babl/c) were infected with PAO1 (5 × 108 CFU in 0.9% saline)[1]
Dosage: 2.5 μM
Administration: Topical, 3 d
Result: Compared with the use of 0.5 mg/mL Tobramycin alone, the antibacterial rate (0.97%/0.22%) and wound healing rate (35%/36%) were equivalent, and the efficacy was improved by 200 times.
Compared with the use of 1 mg/mL Ciprofloxacin alone, the antibacterial rate (0.45%/0%) and wound healing rate (38%/39%) were equivalent, and the efficacy was improved by 1000 times.
分子量

352.41

Formula

C15H20N4O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibacterial synergist 3 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial synergist 3Antibacterial synergist3Antibacterial synergist-3BacterialP. aeruginosa infectionslas systempqs systemelastasepyocyaniniron deficiencymouse wound infection modelInhibitorinhibitorinhibit

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