2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 45

Anticancer agent 46 (compound 2b) 是一种有效的选择性抗癌剂。Anticancer agent 46 在癌细胞中显示出细胞毒活性。Anticancer agent 46 诱导细胞凋亡 (apoptosis)。Anticancer agent 46 对人血的活化淋巴细胞具有低毒性。

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Anticancer agent 45 Chemical Structure

Anticancer agent 45 Chemical Structure

CAS No. : 2770943-87-6

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Anticancer agent 45 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 46 (compound 2b) is a potent and selective anticancer agent. Anticancer agent 46 shows cytotoxicity activity in cancer cells. Anticancer agent 46 induces apoptosis. Anticancer agent 46 shows low toxicity towards activated lymphocytes of human blood[1].

体外研究
(In Vitro)

Anticancer agent 46 (compound 2b) (0-100 µM; 72 h) shows antitumor activity with GI50S of 1.30, 7.25, 4.00, 6.20, 8.00, 6.13, 4.52, 5.65, 1.10, >100, 73.62 µM for Jurkat, A549, MCF-7, MDA-MB-231, KB3-1, HeLa, HCT-116, HCT-116 p53-/-, U251, SK-OV-3, HaCaT cells, respectively[1].
Anticancer agent 46 (1.5 µM; 24 h) induces apoptosis by increases the expression of caspase 3, Bax and decreases the amount of anti-apoptotic Bcl-2 protein[1].
Anticancer agent 46 (compound 2b) (0-2 µM; 24, 48 h) shows low toxicity towards normal human keratinocytes of HaCaT line and mitogen-activated lymphocytes of peripheral blood of healthy human donor[1].
Anticancer agent 46 dose not induce significant DNA damage and changes in morphology of mitogen-activated lymphocytes of peripheral blood of healthy donor[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 45 相关抗体:

Western Blot Analysis[1]

Cell Line: Jurkat cells
Concentration: 1.5 µM
Incubation Time: 24 h
Result: Increased in the amount of pro-apoptotic proteins: caspase 3, Bax, and decreased the amount of anti-apoptotic Bcl-2 protein.
分子量

515.95

Formula

C22H14ClN3O6S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 45 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 452770943-87-6Anticancer agent45Anticancer agent-45ApoptosisAntitumorkeratinocytesmitogen-activatedlow toxicityInhibitorinhibitorinhibit

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