2. Anti-infection
  3. Parasite Bacterial
  4. Antileishmanial agent-22

Antileishmanial agent-22 (compound 15b) 是一种寄生虫抑制剂和抗菌剂，具有抗利什曼原虫、抗疟疾和抗结核活性。Antileishmanial agent-22 基于抗叶酸机制来抑制利什曼原虫 (IC50=0.408 μM)。并且，Antileishmanial agent-22 在 100 μM 浓度下抑制叶酸和亚叶酸，抑制率分别为 88% 和 94%。Antileishmanial agent-22 在体内抑制伯氏疟原虫，在 48.4 μM/kg/day 剂量下的抑制率为 96.67%，或者在体外抑制，IC50=0.038 μM。此外，Antileishmanial agent-22 可抑制结核分枝杆菌，MIC 为 28.44 μM。

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Antileishmanial agent-22 Chemical Structure

Antileishmanial agent-22 Chemical Structure

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Antileishmanial agent-22 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antileishmanial agent-22 (compound 15b) is a parasite inhibitor and an antibacterial agent, with antileishmanial, antimalarial, and anti-tubercular activities. Antileishmanial agent-22 inhibits leishmanial (IC50=0.408 μM) based on antifolate mechanism. And, Antileishmanial agent-22 inhibits Folic acid and Folinic acid at 100 μM with inhibitory rates of 88% and 94%, respectively. Antileishmanial agent-22 inhibits P. berghei in vivo and in vitro, with 96.67% suppression under 48.4 μM/kg/day and 0.038 μM (IC50), respectively. Moreover, Antileishmanial agent-22 inhibits M. tuberculosis with MIC of 28.44 μM[1].

IC50 & Target

IC50: 0.408 μM (leishmanial), 0.038 μM (P. berghei); MIC: 28.44 μM (M. tuberculosis)[1]
体内研究
(In Vivo)

Antileishmanial agent-22 (compound 15b)

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

549.45

Formula

C29H26Cl2N4O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antileishmanial agent-22 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antileishmanial agent-22Antileishmanial agent22Antileishmanial agent 22ParasiteBacterialLeishmaniaMDMalariaNTDOne-potTuberculosistetrahydrobenzo[h]quinolineInhibitorinhibitorinhibit

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