1. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  2. Apoptosis Reactive Oxygen Species (ROS)
  3. Antitumor agent-204

Antitumor agent-204 (compound 15a) 是一种有效的抗肿瘤药物。Antitumor agent-204 具有细胞毒性。Antitumor agent-204 诱导一氧化氮 (NO) 释放和活性氧 (reactive oxygen species) 生成。Antitumor agent-204 诱导细胞凋亡,并诱导细胞周期停滞于 G2/M 期。Antitumor agent-204 表现出抗肿瘤活性。

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Antitumor agent-204 Chemical Structure

Antitumor agent-204 Chemical Structure

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-204 (compound 15a) is a potent antitumor agent. Antitumor agent-204 shows cytotoxicity. Antitumor agent-204 induces nitric oxide (NO) release and reactive oxygen species (ROS) generation. Antitumor agent-204 induces apoptosis and induces cell cycle arrest at G2/M phase. Antitumor agent-204 shows antitumor activity[1].

体外研究
(In Vitro)

Antitumor agent-204 (compound 15a) (0-10 μM; 48 h) shows cytotosicity for A549, A549/Taxol MDA-MB-231, MCF-7, BEAS-2B, HUVEC cells with IC50s of 4.43, 0.87, 1.20, 5.54, 10.73, 13.25 μM, respectively[1].
Antitumor agent-204 (1, 2.5, 5 μM; 24 h) induces cell apoptosis in a dose-dependentmanner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: A549, A549/Taxol, MDA-MB-231, MCF-7, BEAS-2B, HUVEC cells
Concentration: 0-10 μM
Incubation Time: 48 h
Result: Showed cytotoxicity for A549, A549/Taxol MDA-MB-231, MCF-7, BEAS-2B, HUVEC cells with IC50s of 4.43, 0.87, 1.20, 5.54, 10.73, 13.25 μM, respectively.

Apoptosis Analysis[1]

Cell Line: A549/Taxol cells
Concentration: 1, 2.5, 5 μM
Incubation Time: 24 h
Result: Induced cell apoptosis in a dose-dependentmanner.
体内研究
(In Vivo)

Antitumor agent-204 (1, 5, 10 mg/kg; IP; once every 4 days for 16 days) 在小鼠中显示出抗肿瘤活性[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice (A549/Taxol cells)[1]
Dosage: 1, 5, 10 mg/kg
Administration: IP; Once every 4 days for 16 days
Result: Showed antitumor activity by significantly inhibited tumor growth by 50.2 %, 61.2 %, and 72.3 % (w/w) at 1, 5, and 10 mg/kg, respectively.
分子量

703.76

Formula

C39H33N3O8S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Antitumor agent-204
目录号:
HY-176738
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