2. Protein Tyrosine Kinase/RTK JAK/STAT Signaling Epigenetics Stem Cell/Wnt
  3. c-Fms JAK STAT
  4. Anumigilimab

Anumigilimab  (Synonyms: 安米利单抗; CSL-324)

目录号: HY-P99440 纯度: 98.43%
COA 技术支持

Anumigilimab (CSL-324) 是一种人源 IgG4 单抗，靶向人粒细胞集落刺激因子 (G-CSF) 受体。Anumigilimab 可用于炎症部位中性粒细胞数量增加的研究。

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CAS No. : 2416593-08-1

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规格 价格 是否有货 数量
1 mg ￥3000
In-stock
5 mg ￥7800
In-stock
10 mg   询价  
50 mg   询价  

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Anumigilimab 相关抗体

Top Publications Citing Use of Products

查看 JAK 亚型特异性产品:

查看所有亚型
JAK1 JAK2 JAK3 Tyk2 JAK

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anumigilimab (CSL-324) is an human IgG4 mAb against human granulocyte colony-stimulating factor (G-CSF) receptor. Anumigilimab can be used for increasing numbers of neutrophils at sites of inflammation[1][2].

同型

Human IgG4 kappa
推荐同型对照抗体
种属

Human
IC50 & Target

CSF3R
体外研究
(In Vitro)

Anumigilimab (0-100 nM, 48h) 通过阻断 G-CSF 与 G-CSFR 结合来抑制 JAK-1/2 的活化，从而抑制 STAT3 的磷酸化并减少中性粒细胞的增殖和集落形成[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anumigilimab 相关抗体:

Cell Viability Assay[3]

Cell Line: human neutrophils isolated from human peripheral blood
Concentration: 0-100 nM
Incubation Time: 48 h
Result: Inhibited cell viability.
体内研究
(In Vivo)

Anumigilimab (0.1-10 mg/kg, iv, single dose) 可在食蟹猴模型中控制 G-CSF 介导的中性粒细胞增多症[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus macaque models[3]
Dosage: 0.1-10 mg/kg
Administration: iv, single dose
Result: Controled G-CSF mediated neutrophilia in cynomolgus macaque models without causing neutropenia.
Clinical Trial
基因 ID

1441  [NCBI]

Accession

Q99062
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

143.86 kDa

同用名

安米利单抗; CSL-324

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

安米利单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
纯度 & 产品资料
参考文献

Anumigilimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anumigilimab2416593-08-1CSL-324安米利单抗CSL324CSL 324c-FmsJAKSTATCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1RJanus kinaseInhibitorinhibitorinhibit

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