2. Protein Tyrosine Kinase/RTK
  3. c-Kit
  4. APcK110

APcK110 是一种有效的 Kit 抑制剂，可用于急性髓性白血病 (AML) 的研究。APcK110 诱导 AML 细胞凋亡 (apoptosis)。

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APcK110 Chemical Structure

APcK110 Chemical Structure

CAS No. : 1001083-74-4

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APcK110 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

APcK110 is a potent Kit inhibitor that can be used for the research of acute myeloid leukemia (AML). APcK110 induces AML cell apoptosis[1].

体外研究
(In Vitro)

APcK110 (0-500 nM; 0-72 h) 抑制 AML 细胞活力和增殖。APcK110 优先抑制 KIT 突变的 BaF3 细胞株[1]。
APcK110 (0-500 nM; 30 min) 抑制 Kit、Stat3、Stat5 和 Akt 的磷酸化[1]。
APcK110 (500 nM; overnight) 诱导 OCI/AML3 细胞 caspase 依赖性凋亡[1]。
APcK110 (50-500 nM; 7 days) 抑制 AML 原细胞集落形成细胞增殖[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

APcK110 相关抗体:

Cell Proliferation Assay[1]

Cell Line: OCI/AML3, HMC1.2, BaF3 and mutant KIT-expressing BaF3 cells
Concentration: 0-500 nM
Incubation Time: 0, 24, 48 and 72 h
Result: Inhibited proliferation in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: OCI/AML3 and HMC1.2
Concentration: 0, 50, 100, 250 and 500 nM
Incubation Time: 30 min
Result: Showed a dose-dependent inhibition of the phosphorylation of Kit, Stat3, Stat5, and Akt, a downstream effector of phosphatidylinositol 3-kinase.

Apoptosis Analysis[1]

Cell Line: OCI/AML3 cells
Concentration: 500 nM
Incubation Time: Overnight
Result: Induced apoptosis by activation of the caspase pathway.

Cell Cycle Analysis[1]

Cell Line: OCI/AML3 cells
Concentration: 500 nM
Incubation Time: 2 h
Result: Showed a shift of cells into sub-G0 following a 2 h incubation.
体内研究
(In Vivo)

APcK110 (500 nM; i.p.; every other day for 60 days) 在小鼠中显示抗 AML 活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-weeks-old female NODSCID mice, OCI/AML3 xenograft mouse model[2]
Dosage: 500 nM
Administration: Intraperitoneal injection, every other day for 60 days
Result: Survival of compound-treated mice was significantly longer compared with mice injected with PBS.
分子量

349.36

Formula

C20H16FN3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

APcK110 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

APcK1101001083-74-4APcK 110APcK-110c-KitSCFRCD117AMLacute myeloid leukemiaOCI/AML3HMC1.2BaF3Inhibitorinhibitorinhibit

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产品名称：
APcK110
目录号：
HY-110071
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