1. Apoptosis
  2. Apoptosis
  3. Apoptosis inducer 18

Apoptosis inducer 18 一种有效的凋亡诱导剂,对乳腺癌细胞系 MCF-7 显示出显著的细胞毒性 (IC50=0.559 μM)。Apoptosis inducer 18 通过与 DNA 结合并引起损伤,且与 CDK-2 的活性位点结合,干扰其激酶活性,从而抑制细胞周期的进展并促进凋亡。Apoptosis inducer 18 可用于抗乳腺癌的研究。

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Apoptosis inducer 18 Chemical Structure

Apoptosis inducer 18 Chemical Structure

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apoptosis inducer 18, a potent inducer of apoptosis, shows significant cytotoxicity to the breast cancer cell line MCF-7 (IC50=0.559 μM). Apoptosis inducer 18 inhibits cell cycle progression and promotes apoptosis by binding to DNA and causing damage, and by binding to the active site of CDK-2, interfering with its kinase activity. Apoptosis inducer 18 can be used in anti-breast cancer research[1].

分子量

272.28

Formula

C8H12N6O3S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Apoptosis inducer 18 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Apoptosis inducer 18
目录号:
HY-163566
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