2. Immunology/Inflammation
  3. NO Synthase
  4. AR-C102222 hydrochloride

AR-C102222 hydrochloride 

目录号: HY-12122A 纯度: 98.80%
COA 产品使用指南

摩尔计算器

AR-C102222 hydrochloride 是一种有效的、竞争性的、有口服活性的、高度选择性的诱导型一氧化氮合酶 (iNOS) 抑制剂，IC50 值为 37 nM。AR-C102222 hydrochloride 具有抗伤害和抗炎活性。

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AR-C102222 hydrochloride Chemical Structure

AR-C102222 hydrochloride Chemical Structure

CAS No. : 1781934-50-6

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规格 价格 是否有货
5 mg ￥2800
询问价格 & 货期
10 mg ￥4500
询问价格 & 货期
25 mg ￥9000
询问价格 & 货期

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Customer Review

AR-C102222 hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM[1]. AR-C102222 hydrochloride has antinociception and anti-inflammatory activities[2].

体内研究
(In Vivo)

AR-C102222 (3, 10, 30, 100 mg/kg, P.O.) attenuates arachidonic acid-induced ear inflammation and possesses anti-inflammatory activity[2].
AR-C102222 shows good efficacy in a rat adjuvant-induced arthritis model[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Balb/c mice (20-25 g)[2].
Dosage: 3, 10, 30, 100 mg/kg.
Administration: P.O. 55 min before the administration of 0.6% acetic acid (i.p., 1 mL/100 g volume).
Result: Significantly inhibited arachidonic acid-induced ear inflammation following a dose of 100 mg/kg of has a maximal inhibition of approximately 79%.
分子量

418.83

Formula

C19H17ClF2N6O
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

AR-C102222 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AR-C1022221781934-50-6NO SynthaseNitric oxide synthasesNOSAntinociceptionArthritisInhibitorinhibitorinhibit

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目录号：
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