2. Epigenetics
  3. Histone Demethylase
  4. Arborinine

Arborinine 是一种有效的口服活性 LSD1 抑制剂。Arborinine 增加 H3K4me1/2、H3K9me1/2、E-cad 蛋白的表达并降低 UBE2O 蛋白水平的表达。Arborinine 诱导细胞周期停滞在 S 期。Arborinine 具有抗肿瘤活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Arborinine Chemical Structure

Arborinine Chemical Structure

CAS No. : 5489-57-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Arborinine 相关抗体

Top Publications Citing Use of Products

查看 Histone Demethylase 亚型特异性产品:

查看所有亚型
KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Arborinine is a potent and orally activeLSD1 inhibitor. Arborinine increases the expression of H3K4me1/2, H3K9me1/2, E-cad protein and decreases the expression of UBE2O protein level. Arborinine induces cell cycle arrest at S phase. Arborinine shows antitumor activity [1][2].

IC50 & Target[2]

LSD1

 

体外研究
(In Vitro)

Arborinine (0, 5, 15, 30 µM; 48 h) 增加 H3K4me1/2、H3K9me1/2、E-cad 蛋白的表达[1]。
Arborinine (20 µM) 降低 786O 细胞中 UBE2O 蛋白水平的表达[1]。
Arborinine (20 µM) 诱导细胞周期停滞在 S 期并抑制细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Arborinine 相关抗体:

Cell Proliferation Assay[1]

Cell Line: 786O, A498, 769P, Caki1, OSRC2 cells
Concentration: 0-100 µM
Incubation Time: 48, 72 h
Result: Showed antiproliferative activity with IC50s of 30.62, 39.09, 15.67, 31.42, 30.35 µM at 48 h, 20.92, 27.01, 14.94, 30.26, 17.37 µM at 72 h for 786O, A498, 769P, Caki1, OSRC2 cells, respectively.

Western Blot Analysis[1]

Cell Line: 786O cells
Concentration: 0, 5, 15, 30 µM
Incubation Time: 48 h
Result: Increased the expression of H3K4me1/2 and H3K9me1/2 protein in a dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: 786O and A498 cells
Concentration: 20 µM
Incubation Time:
Result: Induced increased population in S phase and decreased population in G1 phase, significantly inhibited both early and late apoptosis of ccRCC cells
体内研究
(In Vivo)

Arborinine (40、80 mg/kg；灌胃； 21 天) 在小鼠体内显示出抗肿瘤活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (SGC-7901 cells and SGC-7901/ADR cells)[2]
Dosage: 40, 80 mg/kg
Administration: P.o.; for 21 days
Result: Inhibited the growth of tumors while unchanged the body weights.
分子量

285.29

Formula

C16H15NO4
CAS 号
结构分类
初始来源

Globigerina parva
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Arborinine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Arborinine5489-57-6Histone DemethylaseH3K4me1/2H3K9me1/2E-cad786O cellsS phaseantitumororally activeInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Arborinine
目录号：
HY-128912
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z